The inflammatory potential of diet is associated with breast cancer risk in Urban Argentina: a multilevel analysis.

NICLIS C; TUMAS N; HEBERT JAMES; SHIVAPPA N; DIAZ MP

NUTRITION AND CANCER

LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS

Lugar: Londres; Año: 2020 p. 1 - 10

0163-5581

Previous studies have shown that diets rich in pro-inflammatory components such as fatty meats and baked goods are associated with breast cancer (BC) in Argentina. However, little evidence relating the inflammatory potential of diet to BC exists in Latin American countries. Therefore, the aim of the present study was to evaluate the association between the Dietary Inflammatory Index (DII®) and BC risk in Córdoba, Argentina. A frequency-matched case-control study (N=843, including 317 BC cases and 526 controls was conducted in Córdoba (Argentina) from 2008 through 2016. DII® scores were computed based on dietary intake assessed by a validated food frequency questionnaire (FFQ). Multi-level logistic regression models were fit to evaluate the association between DII scores and BC, adjusting for age, body mass index, age at menarche, number of children, smoking habits, socio-economic status and family history of BC as first-level covariates and level of urbanization as the contextual variable. Increasing DII score showed significant positive associations with BC risk, Odds of BC increased linearly with increasing DII scores (ORcontinuous 1.08; 95%CI 1.01, 1.19 and ORtertile3 vs. tertile1 1.34; 95%CI 1.05, 1.70). The association was stronger in overweight and obese women (ORtertile3 vs. tertile1 1.98; 95%CI1.86, 2.10). The inflammatory effect of diet was stronger with increased urbanization. A pro-inflammatory diet, reflected by higher DII scores, was positively associated with BC, especially in overweight and obese women and with increased urbanization.Key words: Breast cancer, dietary inflammatory index, urbanization, Argentina.