INVESTIGADORES
MARTIN Pedro
artículos
MONAT, JULIANA; ALTIERI, LUCÍA GONZÁLEZ; ENRIQUE, NICOLÁS; SEDÁN, DANIELA; ANDRINOLO, DARÍO; MILESI, VERÓNICA; MARTÍN, PEDRO
Direct Inhibition of BK Channels by Cannabidiol, One of the Principal Therapeutic Cannabinoids Derived from Cannabis sativa
JOURNAL OF NATURAL PRODUCTS; Lugar: Washington; Año: 2024
LLANOS, MANUEL A.; ENRIQUE, NICOLÁS; ESTEBAN-LÓPEZ, VEGA; SCIOLI-MONTOTO, SEBASTIAN; SÁNCHEZ-BENITO, DAVID; RUIZ, MARÍA E.; MILESI, VERONICA; LÓPEZ, DOLORES E.; TALEVI, ALAN; MARTÍN, PEDRO; GAVERNET, LUCIANA
A Combined Ligand- and Structure-Based Virtual Screening To Identify Novel NaV1.2 Blockers: In Vitro Patch Clamp Validation and In Vivo Anticonvulsant Activity
JOURNAL OF CHEMICAL INFORMATION AND MODELING; Año: 2023 vol. 63 p. 7083 - 7096
LLANOS, MANUEL A.; ENRIQUE, NICOLÁS; SBARAGLINI, MARÍA L.; GAROFALO, FEDERICO M.; TALEVI, ALAN; GAVERNET, LUCIANA; MARTÍN, PEDRO
Structure-Based Virtual Screening Identifies Novobiocin, Montelukast, and Cinnarizine as TRPV1 Modulators with Anticonvulsant Activity In Vivo
JOURNAL OF CHEMICAL INFORMATION AND MODELING; Año: 2022 vol. 62 p. 3008 - 3022
LLANOS, MANUEL A.; VENTURA, CLARA; MARTÍN, PEDRO; ENRIQUE, NICOLÁS; FELICE, JUAN I.; GAVERNET, LUCIANA; MILESI, VERÓNICA
Novel Dimeric hHv1 Model and Structural Bioinformatic Analysis Reveal an ATP-Binding Site Resulting in a Channel Activating Effect
JOURNAL OF CHEMICAL INFORMATION AND MODELING; Año: 2022 vol. 62 p. 3200 - 3212
MARTÍN, PEDRO; MONCADA, MELISA; CASTILLO, KAREN; ORSI, FEDERICO; DUCCA, GERÓNIMO; FERNÁNDEZ-FERNÁNDEZ, JOSÉ MANUEL; GONZÁLEZ, CARLOS; MILESI, VERÓNICA
Arachidonic acid effect on the allosteric gating mechanism of BK (Slo1) channels associated with the β1 subunit
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES; Año: 2021 vol. 1863
ENRIQUE, ANDREA (EQUAL CONTRIBUTION); MARTÍN, PEDRO (EQUAL CONTRIBUTION); SBARAGLINI, MARÍA LAURA; TALEVI, ALAN; MILESI, VERÓNICA
Parabens inhibit hNaV 1.2 channels
BIOMEDICINE & PHARMACOTHERAPY = BIOMEDECINE & PHARMACOTHERAPIE.; Año: 2020 vol. 128
VENTURA, CLARA; LEON, IGNACIO ESTEBAN; ASUAJE, AGUSTIN; MARTÍN, PEDRO; ENRIQUE, NICOLAS; NÚÑEZ, MARIEL; COCCA, CLAUDIA; MILESI, VERÓNICA
Differential expression of the long and truncated Hv1 isoforms in breast‐cancer cells
JOURNAL OF CELLULAR PHYSIOLOGY; Lugar: New York; Año: 2020
SABATIER, LAUREANO L.; PALESTRO, PABLO H.; ENRIQUE, ANDREA V.; PASTORE, VALENTINA; SBARAGLINI, MARÍA L.; MARTÍN, PEDRO; GAVERNET, LUCIANA
Design, synthesis and biological evaluation of N-substituted α-hydroxyimides and 1,2,3-oxathiazolidine-4-one-2,2-dioxides with anticonvulsant activity
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY; Año: 2019 vol. 34 p. 1465 - 1473
ASUAJE, AGUSTÍN; MARTÍN, PEDRO; ENRIQUE, NICOLÁS; DÍAZ ZEGARRA, LEANDRO AGUSTÍN; SMALDINI, PAOLA; DOCENA, GUILLERMO; MILESI, VERÓNICA
Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs
CHANNELS; Año: 2018 vol. 12 p. 58 - 60
PALESTRO, PABLO; ENRIQUE, NICOLAS; GOICOECHEA, SOFIA; VILLALBA, MARÍA LUISA; SABATIER, LAUREANO LEONEL; MARTIN, PEDRO; MILESI, VERONICA; BRUNO-BLANCH, LUIS E.; GAVERNET, LUCIANA
Searching for new leads to treat epilepsy. Target-based virtual screening for the discovery of anticonvulsant agents.
JOURNAL OF CHEMICAL INFORMATION AND MODELING; Lugar: Washington; Año: 2018
CASTILLA, ROCÍO; ASUAJE, AGUSTÍN; RIVIÈRE, STÉPHANIE; ROMERO, CAIMI GISELLE; MARTÍN, PEDRO; CAO, GABRIEL; KLEIMAN DE PISAREV, DIANA; MILESI, VERÓNICA; ALVAREZ, LAURA
Environmental pollutant hexachlorobenzene induces hypertension in a rat model
CHEMOSPHERE; Año: 2018 vol. 195 p. 576 - 584
PASTORE, VALENTINA; WASOWSKI, CRISTINA; MARTIN, PEDRO; ENRIQUE, ANDREA; HIGGS, JOSEFINA; BRUNO-BLANCH, LUIS E.; MILESI, VERONICA; MARDER, MARIEL
N-propyl-2,2-diphenyl-2-hydroxyacetamide, a novel α-hydroxyamide with anticonvulsant, anxiolytic and antidepressant-like effects that inhibits voltage-gated sodium channels
EUROPEAN JOURNAL OF PHARMACOLOGY; Año: 2018 vol. 819 p. 270 - 280
MARTÍN, PEDRO; MONCADA, MELISA; KUNTAMALLAPPANAVAR, GURUPRASAD; DOPICO, ALEX M; MILESI, VERÓNICA
Activation of human smooth muscle BK channels by hydrochlorothiazide requires cell integrity and the presence of BK β1 subunit
ACTA PHARMACOLOGICA SINICA; Año: 2018 vol. 39 p. 371 - 381
ASUAJE, AGUSTÍN; SMALDINI, PAOLA; MARTÍN, PEDRO; ENRIQUE, NICOLÁS; ORLOWSKI, ALEJANDRO; AIELLO, ERNESTO A.; GONZALEZ LEÓN, CARLOS; DOCENA, GUILLERMO; MILESI, VERÓNICA
The inhibition of voltage-gated H+ channel (HVCN1) induces acidification of leukemic Jurkat T cells promoting cell death by apoptosis
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY; Año: 2017 vol. 469 p. 251 - 261
STRINGA, P; ROMANIN, D; LAUSADA, N; PAPA GOBBI, R; ZANUZZI, C; MARTÍN, P; ABATE, JC; CAVANNE, A; ARNAL, N; VECCHIO, L; MILESI, V; PORTIANSKY, E; GONDOLESI, G; RUMBO, M
Gut permeability and glucose absorption are affected at early stages of graft rejection in a small bowel transplant rat model
Transplantation Direct; Año: 2017 vol. 3
MARTIN, P; MONCADA, M; ENRIQUE, N; ASUAJE, A; VALDEZ CAPUCCINO, JM; GONZÁLEZ, C; MILESI, V
Arachidonic acid activation of BKCa (Slo1)channel associated to β1 subunit in human vascular smooth muscle cells.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY; Lugar: Berlin; Año: 2013 vol. 466 p. 1779 - 1792
MARTÍN, P; REBOLLEDO, A; ROLDÁN PALOMO, AR; MONCADA, M; PICCININI, L; MILESI, V
Potassium channels diversity in human umbilical artery (HUA) smooth muscle cells. A review of their roles in HUA contraction.
REPRODUCTIVE SCIENCES; Lugar: Thousand Oaks, California.; Año: 2013 vol. 21 p. 432 - 441
ENRIQUE, N; REBOLLEDO, A; MARTÍN, P; ROLDÁN PALOMO, AR; TANZI, F; MILESI, V
Extracellular ATP induces fast and transient non-selective cationic currents and cytosolic Ca(2+) changes in human umbilical artery smooth muscle cells.
PURINERGIC SIGNALLING; Lugar: Berlin; Año: 2012 vol. 8 p. 199 - 206
ROLDÁN PALOMO, AR; MARTÍN, P; REBOLLEDO, A; ENRIQUE, N; FLORES, LE; MILESI, V
Human umbilical artery smooth muscle exhibits a 2-APB-sensitive capacitative contractile response evoked by vasoactive substances and expresses mRNAs for STIM, Orai and TRPC channels
BIOCELL; Lugar: Mendoza; Año: 2012 vol. 36 p. 73 - 81
MARTÍN, P; ENRIQUE, N; ROLDÁN PALOMO, AR; REBOLLEDO, A; MILESI, V
Bupivacaine inhibits large conductance, voltage- and Ca ( 2+) - activated K (+) channels in human umbilical artery smooth muscle cells.
CHANNELS; Lugar: Austin, Texas; Año: 2012 vol. 6 p. 174 - 180
IVELI, MF; REBOLLEDO, A; MARTIN, P; ENRIQUE, N; ROLDÁN PALOMO, AR; RIMORINI, L; SALEMME, S; MILESI, V
Risperidone Inhibits Contractions Induced by Serotonin and Histamine and Reduces K+ Currents in Smooth Muscle of Human Umbilical Artery.
REPRODUCTIVE SCIENCES; Lugar: Thousand Oaks, Calif.; Año: 2010 vol. 17 p. 854 - 860
HERCE, HD; GARCIA, AE; LITT, J; KANE, RS; MARTIN, P; ENRIQUE, N; REBOLLEDO, A; MILESI, V
Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell-penetrating peptides.
BIOPHYSICAL JOURNAL; Lugar: Cambridge, MA; Año: 2009 vol. 97 p. 1917 - 1925