MECHANISMS UNDERLYING THE ANTI-TUMORAL EFFECTS OF THE FLAVONOID 2’-NITROFLAVONE IN HUMAN TRIPLE-NEGATIVE BREAST CANCER CELLS

VANINA SOL VACHETTA ; VIVIANA BLANK; MILAGROS BUSTOS; MARIEL MARDER; MARÍA GABRIELA ORTEGA; MARGOT PAULINO ZUNINI; MARÍA TERESA ELOLA; MARÍA FERNANDA TRONCOSO

Mar del Plata

Congreso; JOINT MEETING SAIC SAI&FAIC SAFIS 2022; 2022

Triple-negative breast cancer (TNBC) is one the most aggressivesubtypes of mammary tumors. Flavonoids are polyphenolic compoundsthat cause several antineoplastic effects. We previouslydescribed that the synthetic flavonoid 2’-nitroflavone (2’NF) inhibitsviability, survival and migration of human TNBC cells. Herein, ouraim pointed to find out mechanisms that mediate 2’NF anti-tumoraleffects in these cells. We first evaluated MDA-MB-231 cell cycle progression(propidium iodide staining, flow cytometry) upon treatment.2’NF (5 mM, 72 h) decreased the percentage of cells in G1 phasefrom 59.30±1.63 (control) to 43.00±.2.29% (p