INVESTIGADORES
MARDER Nora mariel
artículos
Título:
6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.
Autor/es:
M. MARDER; H. VIOLA; C. WASOWSKI; C. WOLFMAN; P. G. WATERMAN; B. K. CASSELS; J. H. MEDINA; A. C. PALADINI
Revista:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Referencias:
Año: 1996 vol. 223 p. 284 - 389
ISSN:
0006-291X
Resumen:
6-bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors with a Ki= 70 nM and has a clear anxiolytic activity in mice, at 0.5 mg/kg, i.p. A survey of the structure/affinity relationship for those receptors in a series of natural and synthetic flavonoids is presented
