INVESTIGADORES
MARDER Nora mariel
artículos
Título:
6,3'-Dinitroflavone: a high affinity ligand for the BZD-R with potent anxiolytic properties.
Autor/es:
M. MARDER; H. VIOLA; C. WASOWSKI; C. WOLFMAN; P. WATERMAN; J. H. MEDINA; A. C. PALADINI
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Referencias:
Año: 1995 vol. 5 p. 2717 - 2720
ISSN:
0960-894X
Resumen:
6,3-Dinitroflavone (2) and 6,4-dinitroflavone (3), prepared by direct nitration of flavone (1), were found to be ligands for the benzodiazepine receptor (BDZ-R). Compound 2, with a Ki= 12 nM, produced potent anxiolytic effects in mice at a dose of 1 mg/Kg.
