Polyphenols of peanut (Arachis hypogaea L.) skin as bioprotectors of normal cells. Studies of cytotoxicity, cytoprotection and interaction with ROS

ROSSI, YANINA E.; BOHL, LUCIANA P.; VANDEN BRABER, NOELIA L.; BALLATORE, MARÍA B.; ESCOBAR, FRANCO M.; BODOIRA, ROMINA; MAESTRI, DAMIÁN M.; PORPORATTO, CARINA; CAVAGLIERI, LILIA R.; MONTENEGRO, MARIANA A.

Journal of Functional Foods

Elsevier

Año: 2020 vol. 67

1756-4646

Arachis hypogaea L. (peanut) skin is a potential source of natural antioxidants, and several studies have suggestedthe possibility of producing functional ingredients from this by-product of food industry. This investigationexamined possible toxic effects of peanut skin polyphenolic extract (PSE) and its antioxidant properties using invitro studies. PSE and its main component quercetin (QE) did not present any cytotoxicity on normal epithelialcells, rat ileum cells (IEC-18), monkey kidney cells (Vero) or human peripheral blood mononuclear cells (PBMCs)at concentrations with antioxidant effects. QE and PSE showed scavenging of the superoxide anion radical andcytoprotection, as well as reducing the reactive oxygen species (ROS) and superoxide dismutase (SOD) activity inIEC-18 cells against menadione-induced oxidative stress. This suggests that peanut skin phenolic extract could bea potential functional ingredient for foods.