Vitamin Producing Lactic Acid Bacteria, Novel Uses

J.G. LEBLANC; R. LEVIT; G. SAVOY DE GIORI; A. DE MORENO DE LEBLANC

Praga

Congreso; 14th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health ? IPC2020; 2020

IntroductionIt has been shown that Lactic Acid Bacteria (LAB) have the ability to produce bioactive compounds including the water soluble B group vitamins (folate, riboflavin and thiamine) in a strain dependent manner.MethodsGrowth media, food matrix and the conditions of the gastrointestinal tract can all affect vitamin production. Wild type strains isolated from a wide range of ecological niches (foods, animals, plants) and genetically modified LAB have been used in order to produce novel foods with elevated vitamin concentrations.ResultsThese vitamin bioenriched foods, or the vitamin producing strains themselves, have been able to prevent and treat vitamin deficiencies in different laboratory animal models and could be used for human consumption or animal production. Furthermore, other non-nutritional functional properties of vitamin producing LAB have been demonstrated in cell culture and animal models. It has been shown that selected folate, riboflavin and thiamine producing LAB can be used to prevent or treat many physiological disorders such as colitis, mucositis, Parkinson?s Disease, colon and breast cancer in rodent models.DiscussionThese vitamin-producing strains could be used as adjunct treatments against these and other inflammatory diseases through the modulation of the immune response and increasing the well-being of patients without affecting the effectiveness of their primary treatments.