Probiotic interaction with host immunity

GABRIELA, PERDIGÓN; MALDONADO GALDEANO, CAROLINA; CAZORLA, SILVIA INES

Conferencia; XI ISIN Conference on Immunonutrition; 2018

International Society of Immunonutrition

The gastrointestinal tract is the most active microbiologically ecosystems and play a crucial role in the Mucosal Immune System (MIS). Probiotic microorganisms stimulate the Immune System and send signals to: 1) the intestinal epithelial cells and the immune cells associated, to the intestine; 2) the Paneth cells to produce antimicrobial sustances The interactions induce the production of different cytokines from the immune cells with MIS activation. We demonstrate: a) probiotics stimulate the mucosal immunity increasing the number of IgA +intestinal cells, activity of T cells, and induce inmunomodulation by IL10 b) We determined the importance of the probiotic viability c) the interaction with the epithelial cell and macrophages, is Toll like receptors(TLRs) dependent d) probiotics induce an increase in goblet and Paneth cells e) favor the innate immune response, where macrophages and DCs play an important role, without induce an inflammatory response, favoring the expression of regulators proteins to minimize the NFkB activation avoiding proinflammatory cytokines f) probiotics are effective in Salmonella infection by increase of microbicidal activity of macrophages g) In malnutrition models improves the histology of intestine and thymus and the Immune System functionality h) In respiratory allergy model, a PFM diminished the levels of IgE with Th1 balance, favoring the IgG instead of IgE. In conclusion probiotic and PFM have an important role in the functionality of the MIS and in the mechanisms of immunoregulation