INVESTIGADORES
MALDONADO GALDEANO Maria Carolina
capítulos de libros
Título:
Lactic Acid Bacteria as Immunomodulators of the Gut-Associated Immune System
Autor/es:
MALDONADO GALDEANO CAROLINA; DE MORENO DE LEBLANC ALEJANDRA; DOGI, CECILIA; PERDIGÓN GABRIELA
Libro:
Biotecnology of lactic acid bacteria: Novel applications
Editorial:
Wiley- Blackwell
Referencias:
Lugar: USA; Año: 2010; p. 125 - 140
Resumen:
The safety and beneficial effects on human health of
selected lactic acid bacteria (LAB) used as probiotics
in many food products need to be assessed by
rigorous criteria. Several studies have shown that
LAB stimulate the systemic and mucosal immune
systems. To establish the scientific basis for the use
of these microorganisms as immune adjuvants, the
elucidation of the involved mechanisms is needed.
Animal model studies have demonstrated that
mucosa immune activation by different LAB is mediated
by the increase in the numbers of proinflammatory
and regulatory cytokine producing cells in the
gut, thus maintaining the intestinal homeostasis.
LAB administration also showed a tendency to stimulate
the Th2 response with production of systemic
antibodies, bacterial viability being an important
condition. Probiotic LAB can interact with epithelial
cells as well as with the immune cells associated
with the gut to induce immune activation; microbial
cells or their cellular fragments can also be internalized
by the epithelial cells. Secretory IgA, one of
the principal defense antibodies at the intestinal
level, is increased with the administration of probiotic
bacteria. The clonal expansion of T lymphocyte
population in lamina propria of the small intestine
is, however, not induced by LAB. These bacteria
activate mainly the innate immune response (macrophages
and dendritic cells) through the increase
in the expression of receptors involved in the antigen
clearance and in the immune signaling as well as
the reinforcement of the intestinal barrier, thus protecting
the host against intestinal pathologies.