PROBIOTIC LACTOBACILLI: PROMISING STRATEGY TO AMELIORATE DISORDERS ASSOCIATED WITH INTESTINAL INFLAMMATION INDUCED BY A NON-STEROIDAL ANTI-INFLAMMATORY DRUG.

MARTINEZ MONTEROS, MARIA JOSÉ; MALDONADO GALDEANO, CAROLINA; BALCELLS, FLORENCIA; PERDIGÓN, GABRIELA; CAZORLA, SILVIA INES

Scientifc Reports

NATURE

Año: 2021 vol. 11

Damage to the small intestine caused by non-steroidal anti-infammatory drugs (NSAIDs) occursmore frequently than in the upper gastrointestinal tract, is more difcult to diagnose and no efectivetreatments exist. Hence, we investigated whether probiotics can control the onset of this severecondition in a murine model of intestinal infammation induced by the NSAID, indomethacin. Probioticsupplementation to mice reduce the body weight loss, anemia, shortening of the small intestine,cell infltration into the intestinal tissue and the loss of Paneth and Goblet cells associated withintestinal infammation. Furthermore, a high antimicrobial activity in the intestinal fuids of mice fedwith probiotics compared to animals on a conventional diet was elicited against several pathogens.Interestingly, probiotics dampened the oxidative stress and several local and systemic markers ofan infammatory process, as well as increased the secretion of IL-10 by regulatory T cells. Even moreimportantly, probiotics induced important changes in the large intestine microbiota characterizedby an increase in anaerobes and lactobacilli, and a signifcant decrease in total enterobacteria. Weconclude that oral probiotic supplementation in NSAID-induced infammation increases intestinalantimicrobial activity and reinforces the intestinal epithelial barrier in order to avoid pathogens andcommensal invasion and maintain intestinal homeostasis.