Effect of diets enriched with chia oil and different energetic contribution on vascular function

MEDINA, ANALIA; SIERRA, LILIANA; IXTHAINA, VANESA ; ROCO, JULIETA; MARTIN ALZOGARAY, FLORENCIA; TAGASHIRA, CELIA ; JEREZ, SUSANA; MEDINA, MIRTA

Tucumán

Simposio; XXXVI Jornadas Científicas de la Asociación de Biología de Tucumán; 2019

Previously, we observed that a diet supplemented with chia oil (Ch) at 10% has beneficial effects on vascular function in conditions of hypercholesterolemia, but produces glucose intolerance. Our objective was to evaluate if by reducing the % of Ch with which the diet is enriched, the beneficial properties are maintained without altering the metabolism of glucose. Rabbits were fed a control diet (DC), DC plus 3% Ch (Ch 3%) and DC plus 10% Ch (Ch 10%) for 6 weeks. Biochemical, clinical parameters and glucose tolerance test (TTG) were determined. Abdominal visceral fat (AVG) was weighed. Endothelial function was evaluated in isolated aorta by measuring relaxation toacetylcholine (Ach 10-8-10-6M) and vascular reactivity by stimulation with angiotensin II (AngII 10-9-10-6M) or noradrenaline (NA 10-8 -10-5M). Ch 10% and Ch 3% added 25% and 7.5% of calories to DC. No changes were observed in the lipidogram, clinical parameters or in the GVA. Ch 3% did not modify the TTG with respect to DC [(mg/dl), DC: Basal 112±7; 60min 186±5; 120min 140±3- Ch 3%: Basal 116±9; 60min 153±15; 120min 133±11], however the % of relaxation decreased to Ach (%): DC: 60±7 vs Ch 3%: 38%±6,6 vs Ch 10%: 60%±4. Both diets enriched with chia decreased: - RMax to AngII (mg), DC: 4117±114; Ch 3%: 2539±843; Ch 10%: 2755±521 (p˂0.05) - the response to NA (mg), DC: 11237±1234; Ch 3%: 8969±967; Ch 10%: 7042±1008 (p˂0.05). Considering that Ch 3% desensitizes the arteries to vasoconstrictors and does not alter the glucose metabolism, wecan conclude that 3% would be the % and the optimal energy contribution of Ch to improve vascular function and prevent cardiovascular risk.