HELICOBACTER PYLORI INFECTION IN CELIAC DISEASE PATIENTS FROM SAN LUIS, ARGENTINA

A. G. SALINAS IBAÑEZ,; T.I. CORTIÑAS,; C.S. LUCERO ESTRADA,; P.E. GÓMEZ, ; P. VALLEJOS; P BIANCHI, ; M. CELIZ, ; T. ALARCÓN CAVERO,; A. E. VEGA.

Dublin

Congreso; XXIVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer; 2011

European Helicobacter Study Group

Helicobacter pylori is the main etiologic agent of chronic gastritis, peptic ulcer,gastric cancer and MALT lymphoma. Celiac disease (CD) is a constant gluten intolerancethat may affect the morphology and function of the entire gastrointestinal tract. The gluten is a second factor stimulating the rise of MALT neoplasm in celiac patients. The aim of this study was to assess the gastric histological pattern in patients with H. pylori and celiac disease Histological studies, culture and urease test were carried out in biopsy samples of one hundred six patients. Analysis of antigliadin (AGA) and antitransglutaminase antibody (ATA) were performed in blood samples. H. pylori infection was detected in 52.8% of the patients. The CD was confirmed by positive antibodies and histological studies in 23 patients (22%). The changes in villous area (V) and crypt length (C) (V/C ratio) allowed the CD classification by Marsh?s System. Ten (six children and four adults) celiac patients had H. pylori infection associated with chronic gastritis. Regardless of their H. pylori status, all pediatric celiac patients had severe atrophy (grade 4). H. pylori-positive adult celiacs showed more severe atrophy (grade 4) than H. pylori-negative celiac patients (grade 2). Celiac adults infected with H pylori in San Luis Argentina presented more severe histopathological profiles from those H. pylori-negative celiacs patients. The delay in diagnosis of people infected with H. pylori and CD can increase risk of lymphoproliferative lesions.