Aristolochia argentina: Efecto sobre la mucosa gástrica y cepas de Helicobacter pylori

PAREDES J, ; SALINAS AG, ; FUSCO M, ; SOSA A, ; WENDEL G, ; VEGA AE, ; CORTIÑAS TI,; PELZER L

San Juan

Congreso; 2da Reunión Conjunta de Sociedades de Biología; 2011

Sociedad de Biología de Cuyo

Aristolochia argentina (familia Aristolochiaceae), populary know as ?charrúa?, is used in folk medicine. The aim of this study was to assess the anti-ulcerogenic effect in rats and determine the antibacterial activity on H. pylori susceptible and resistant strains. Wistar rats of either sex (200-250g) were employed. We examined the effect of A. argentina on gastric damage induced by oral administration of absolute ethanol (EtOH). The results of the macroscopic evaluation were confirmed by the data obtained by measuring the area of the lesioned mucosa by using a computerbased image analysis. A. argentina prevents the formacion of gastric lesions (% inhibition): 250 mg/kg: 44.89% (p