GASTROPROTECTION AND ANTIMICROBIAL ACTIVITY OF Lithraeamolleoides AND METABOLITES AGAINST Helicobacter pylori

GARRO MF; SALINAS IBAÑEZ AG; VEGA AE ; ARIZMENDI SOSA AC; SAAD JR; MARÍA AO, ; PAREDES J, SALINAS AG, FUSCO M, SOSA A, WENDEL G, VEGA AE, CORTIÑAS TI, PELZER L

San Luis

Congreso; XXX Reunión Anual de la Sociedad de Biología de Cuyo.; 2012

Sociedad de Biología de Cuyo

Lithraea molleoides (Vell.) Engl. (Anacardiaceae), known popularly as ?molle?, is used in folk medicine as digestive. In one study, the antibacterial activity ofL. molleoides was assayed on ten clinical strains of Helicobacter pylori isolated from gastric biopsies, reference strain NCTC 11638, and evaluated by agar diffusion method in well, range 2.5 - 250 mg/ml. The MIC was determined by agar dilution method according to Clinical and Laboratory Standards Institute using dilutions of gallic, caffeic and ferulic acids, rutin, catechol or mannitol compounds isolated (500 to 0.125 μg/ ml). Results indicate that L. molleoides extracts have antimicrobial activity against H. pylori strains and may be due to the presence of different compounds described in the phytochemical profile. In other study, necrotizing agents (0.6N HCl, acetylsalicylic acid 200 mg/ kg or absolute ethanol) were employed as ulcerogenic agents in Wistar rats (Robert et al.). Aqueous and methanolic extracts and metabolites isolated of L. molleoides prevent the formation of gastric lesions (p