BECAS
MAZZITELLI Ignacio Gabriel
congresos y reuniones científicas
Título:
EXTRACELLULAR ACIDOSIS DRIVES THE DIFFERENTIATION OF HUMAN MONOCYTES INTO DENDRITIC CELLS: ROLE OF THE ARYL HYDROCARBON RECEPTOR AND MTOR
Autor/es:
DIAZ, FERNANDO ERRA; DANTAS, EZEQUIEL; DUETTE, GABRIEL; VARESE, AUGUSTO; MAZZITELLI, I.; OCHOA, VALERIA; MIRET, NOELIA; RANDI,ANDREA; SABATTÉ, JUAN; GEFFNER, JORGE
Reunión:
Congreso; Congreso SAIC- SAI-SAFIS 2018; 2018
Resumen:
/LWWOHLVNQRZQDERXWWKHLGHQWLW\RIWKHIDFWRUVWKDWLQYLYRFRQWUROWKHdifferentiation of monocytes into macrophages and dendritic cells'&V/RFDODFLGRVLVLVDFRPPRQIHDWXUHRILQÁDPPDWLRQDQGWKHWXPRU PLFURHQYLURQPHQW :H KDYH SUHYLRXVO\ VKRZQ WKDW ORZ S+(pH 6.5) promotes monocyte differentiation into DCs, in peripheralblood mononuclear cells (PBMCs) or isolated monocytes culturedIRUGD\VZLWK3+$+HUHZHIXUWKHUFKDUDFWHUL]HWKHLQÁXHQFHH[HUWHGE\ORZS+RQWKHGLIIHUHQWLDWLRQRIPRQRF\WHVLQWR'&V3UHYLRXV VWXGLHV VKRZHGWKDW ZKHQ KXPDQPRQRF\WHV ZHUH FXOWXUHGZLWK0&6) QJPO,/ QJPO DQG71)DOID QJPO DPLQRUIUDFWLRQRIFHOOVDFTXLUHDQLQÁDPPDWRU\'&SKHQRW\SH+HUHZHIRXQGWKDWORZS+PDUNHGO\SURPRWHGWKHGLIIHUHQWLDWLRQRIPRQRF\WHVLQWRLQÁDPPDWRU\'&VLQGXFHGE\0&6),/DQG71)DOSKDL'&V YVRI&'D&'&'FHOOV PHDQ6(Q SS+YVUHVSHFWLYHO\,QWHUHVWLQJO\SURPRWLRQRI'&GLIIHUHQWLDWLRQE\ORZS+ZDVDOVRREVHUYHGLQFRQGLWLRQVVWURQJO\DVVRFLDWHGZLWKPDFURSKDJHGLIIHUHQWLDWLRQ,QIDFWZHIRXQGWKDWPRQRF\WHV FXOWXUHG LQ VHUXPIUHHPHGLXPZLWK0&6)(50ng/ml) for 5 days at pH 7.3 or pH 6.5, resulted in 5 ± 5 vs 60 ±RI&'D&'FHOOVPHDQ6(Q S0HFKDQLVWLFVWXGLHVVKRZHGWKDW'&GLIIHUHQWLDWLRQLQGXFHGE\DFLGRVLVZDVprevented by the inhibitor of the of the aryl hydrocarbon receptor$+5VWHPUHJHQLQ0LQKLELWLRQ!Q ,QWHUHVWLQJO\the inhibitor of mTORC1 temsirolimus (1-100 nM) promotes the difIHUHQWLDWLRQRIPRQRF\WHVLQWRL'&VLQDVLPLODUIDVKLRQWKDWORZS+%HFDXVHH[WUDFHOOXODUDFLGRVLVKDVVKRZQWRLQKLELWP725&DFWLYLW\RXUREVHUYDWLRQVVXJJHVWWKDWORZS+SURPRWHV'&GLIIHUHQWLDWLRQWKURXJKDPHFKDQLVPWKDWLQYROYHVWKHLQWHUSOD\EHWZHHQ$+5DQGP725&SDWKZD\V