INVESTIGADORES
CHIESA Ana Elena
congresos y reuniones científicas
Título:
Disfunción neurosecretora de GH (GHNSD) idiopatica: una posible causa de deficiencia de GH (GHD). 11-14 octubre 2008
Autor/es:
A FREIRE,; A KESELMAN,; A CHIESA,; G ROPELATO,; I BERGADA.
Lugar:
Lima Perú.
Reunión:
Congreso; XX Reunion Anual de SLEP; 2008
Institución organizadora:
SLEP
Resumen:
.GHNSD was described by Spiliotis et al in 1984. Since then, this
entity was reported in patients after cranial radiation therapy. However,
the diagnosis of idiopathic GHNSD has been questioned. We describe
3 prepubertal patients aged 12, 7.8 and 6.3 years with height of −4.2,
−3.3 and −4.3 SDS, respectively and delay in bone age from 3 to 5
years. Target height was normal, without a history of constitutional
delay. Psychosocial deprivation was excluded. Arginine-clonidine
tests showed a maximum GH peak of 10.8, 16.8 and 17.1 ng/ml, and
serum IGF1 (SDS) levels were −4.64, −2.3 and −2.8 respectively.
An increase of IGF-1 > 60% in the GH generation tests excluded
GH insensitivity. A twelve-hour 20 minutes sampling nocturnal pulsatile
GH secretion was performed and compared with normal prepubertal
controls (C).
Spontaneous mean ± SD GH levels (ng/ml) were 0.69 ± 0.3,
1.3 ± 0.8 and 1.4 ± 0.8 vs 4.4 ± 1.4 in C. Pulse amplitude were
0.6 ± 0.39, 1.9 ± 2.1 and 3.4 ± 0.37 vs 8.5 ± 4.3 in C. Max GH were
1.21, 4.2 and 4.6 vs 18.2 ± 9.5 in C. All these values were significantly
lower than C, while the number of pulses were not.
GH treatment at a mean dose of 0.23 mg/k/wk resulted in growth
acceleration at year one from a baseline of 4.1, 4.0, and 3.2 cm/yr, to
10.1, 10.2 and 7.6 cm/yr, respectively.
These data show that idiopatic GHNSD should be considered
when other causes of GHD are excluded even without a history of cranial
irradiation. The 12-hour spontaneous nocturnal GH sampling is
an alternative test to delineate who might benefit from GH treatment..GHNSD was described by Spiliotis et al in 1984. Since then, this
entity was reported in patients after cranial radiation therapy. However,
the diagnosis of idiopathic GHNSD has been questioned. We describe
3 prepubertal patients aged 12, 7.8 and 6.3 years with height of −4.2,
−3.3 and −4.3 SDS, respectively and delay in bone age from 3 to 5
years. Target height was normal, without a history of constitutional
delay. Psychosocial deprivation was excluded. Arginine-clonidine
tests showed a maximum GH peak of 10.8, 16.8 and 17.1 ng/ml, and
serum IGF1 (SDS) levels were −4.64, −2.3 and −2.8 respectively.
An increase of IGF-1 > 60% in the GH generation tests excluded
GH insensitivity. A twelve-hour 20 minutes sampling nocturnal pulsatile
GH secretion was performed and compared with normal prepubertal
controls (C).
Spontaneous mean ± SD GH levels (ng/ml) were 0.69 ± 0.3,
1.3 ± 0.8 and 1.4 ± 0.8 vs 4.4 ± 1.4 in C. Pulse amplitude were
0.6 ± 0.39, 1.9 ± 2.1 and 3.4 ± 0.37 vs 8.5 ± 4.3 in C. Max GH were
1.21, 4.2 and 4.6 vs 18.2 ± 9.5 in C. All these values were significantly
lower than C, while the number of pulses were not.
GH treatment at a mean dose of 0.23 mg/k/wk resulted in growth
acceleration at year one from a baseline of 4.1, 4.0, and 3.2 cm/yr, to
10.1, 10.2 and 7.6 cm/yr, respectively.
These data show that idiopatic GHNSD should be considered
when other causes of GHD are excluded even without a history of cranial
irradiation. The 12-hour spontaneous nocturnal GH sampling is
an alternative test to delineate who might benefit from GH treatment.