Cognitive assessment of early detected and treated hypothyroid children

L PARDO CAMPOS, ; M MUSSO ,; A KESELMAN; I BERGADA ; A CHIESA.

Buenos Aires

Congreso; XXVI Congreso de la Sociedad Latinoamericana de Endocrinologia Pediatrica; 2016

Sociedad Latinoamericana de Endocrinologia Pediatrica

Introduction: Children with congenital hypothyroidism (CH)detected through neonatal screening and adequately treated mightpresent mild cognitive deficits possibly related to the underlyingdisease.Objectives: To characterize the cognitive profiles of childrenwith CH, and to assess specific deficits and their relationship withvariables of severity, duration and treatment of the disease.Patients: 60 CH children aged between 9 and 10 years detectedthrough neonatal screening and adequately treated within the firstmonth of age, were selected and compared with a control group of60 healthy children of the same age without CH. Inclusion criteriafor both groups were: absence of other concurrent diseases, halfday school, and parents with complete high school educationallevel.Methods: WISC III, Rey-Osterrieth Complex FigureTest,Woodcock Muñoz?R, Continuous Performance Test (CPT II),ITPA (Illinois test of psycholinguistic abilities), Verbal FluencyTest, Test Knox Cubes, Trail Making Test, Faces Test, and 5 digitsTest were administered.Cognitive profile was related to: 1) LT4 initial dose (10?12 vs.12?16 ug/kg/day), 2) Initial serum T4 level: (≤2 ug/dl vs. >2.1 ug/dl), 3) Etiology: athyreotic vs. ectopic, 4) Age at start of treatment(≤20 vs. 21?30 days) y 5) Epiphyseal Knee surface (≥5 mm2 vs.