GROSS, LZF; GALCERAN, F; SACERDOTI, M; RINALDI, J; KLINKE, S; OTERO, L; LEROUX, AE; BIONDI, RM

In vitro study of the interaction between the protein kinase PDK1 and two kinase substrates

LIX Reunión Científica anual

Lugar: Rosario; Año: 2023;

BIONDI, RM; ALCOBER-BOQUET, L; ZANG, T; PIETSCH, L; SUESS, E; HARTMANN, M; PROSCHAK, E; GROSS, LZF; SACERDOTI, M; ZEUZEM, S; ROGOV, VV; LEROUX, AE; PIIPER, ALBRECHT

A novel mechanism that regulates the interaction of the autophagy receptor p62/SQSTM1 and the autophagosome protein LC3

LIX Reunión Científica anual

Lugar: Rosario; Año: 2023;

SACERDOTI, M; GROSS, LZF; ZEHNDER, K; RILEY, AM; GHODE, A; SUESS, E; CAPPELLARI, MV; KLINKE, S; ANAND, GS; ARAMENDIA, PF; SVERGUN, DI; GRÄWERT, MA; LEROUX, AE; POTTER, B; CAMACHO, CJ; BIONDI, RM

The use of small molecules to modulate full-length PDK1 kinase conformation and substrate specificity towards Akt

LIX Reunión Científica anual

Lugar: Rosario; Año: 2023;

ACEBEDO MARTINEZ, M; SACERDOTI, M; GROSS, LZF; DI LELLA, S; GIRONACCI, M; BIONDI, RM; LEROUX, AE

EXPLORING ALLOSTERY IN ACE2: CAN SMALL MOLECULES AFFECT ENZYME ACTIVITY AND PROTEIN-PROTEIN INTERACTIONS?

LIX Reunión Científica anual

Lugar: Rosario; Año: 2023;

ACEBEDO MARTINEZ, M; SACERDOTI, M; GROSS, LZF; DI LELLA, S; GIRONACCI, M; BIONDI, RM; LEROUX, AE

DEVELOPMENT OF ALLOSTERIC MODULATORS TO REGULATE ENZYMATIC ACTIVITY AND PROTEIN-PROTEIN INTERACTIONS

Frontiers in Biosciences 4

Lugar: Buenos Aires; Año: 2023;

ACEBEDO MARTINEZ, M; SACERDOTI, M; GROSS, LZF; DI LELLA, S; GIRONACCI, M; BIONDI, RM; LEROUX, AE

HARNESSING ALLOSTERY TO MODULATE PROTEIN-PROTEIN INTERACTIONS AND ENZYMATIC ACTIVITY WITH SMALL MOLECULES

International Program in Biomedical Sciences

Lugar: Buenos Aires; Año: 2023;

LEROUX, AE; SACERDOTI, M; GROSS, LZF; ACEBEDO, M; BIONDI, RM

Allostery to disrupt protein-protein interactions with small molecules

LVIII Reunión Científica anual

Lugar: Mendoza; Año: 2022;

GROSS, LISSY ZF; SACERDOTI, M; HICKS, KG; RUTTER, J; LEROUX, AE; KLINKE, S; BIONDI, RM

STUDY OF PDK1 REGULATION BY METABOLITES AND INTERACTION WITH KINASE SUBSTRATES

LVIII Reunión Científica anual

Lugar: Mendoza; Año: 2022;

BIONDI, RICARDO M.; LEROUX, ALEJANDRO E.

PDK1: Model of Allostery for innovative drug discovery

Annual DKTK meeting

Lugar: Heidelberg; Año: 2021;

SACERDOTI, M; GROSS, LZF; FROESE, K; GHODE, A; RILEY, A; KLINKE, S; ANAND, GS; PARIS, K; SUESS, E; CAPPELLARI, MV; ARAMENDIA, PF; LEROUX, AE; POTTER, B; CAMACHO, CJ; BIONDI, RM

The PDK1 conformational landscape

European Chemical Biology Symposium ECBS 2021 Meeting

Lugar: Evento online debido a la pandemia de coronavirus; Año: 2021;

GROSS, LZF; SACERDOTI, M; LEROUX, AE; GHODE, A; ANAND, GS; SCHULZE, J; KLINKE, S; BIONDI, RM

Chemical biology and structural studies on the mechanism of regulation of phosphoinositide-dependent protein kinase 1 (PDK1)

25th Congress and General Assembly of the International Union of Crystallography

Lugar: Modalidad híbrida online y presencial (Praga); Año: 2021;

GROSS, LZF; SACERDOTI, M; LEROUX, AE; SCHULZE, J; HICKS, KG; RUTTER, J; GHODE, A; ANAND, GS; KLINKE, S; BIONDI, RM

Bidirectional and synergistic allosteric regulation by metabolites of the kinase PDK1

XLIX Reunión Anual de la Sociedad Argentina de Biofísica (SAB)

Lugar: Evento online debido a la pandemia de coronavirus; Año: 2021;

SACERDOTI, M; GROSS, LZF; GHODE, A; RILEY, A; KLINKE, S; GANESH, SA ; PARIS, K; SUESS, E; CAPPELLARI, MV; ARAMENDIA, PF; LEROUX, AE; POTTER, B; CAMACHO, CJ; BIONDI, RM

Study of PDK1 kinase conformations and potential regulatory mechanism for substrate activation

XLIX Reunión Anual de la Sociedad Argentina de Biofísica (SAB)

Lugar: Evento online debido a la pandemia de coronavirus; Año: 2021;

SACERDOTI, M; GROSS, LZF; FROESE, KARIN; SUESS, E; GHODE, A; RILEY, A; CAPELLARI, V; KLINKE, S; ANAND, GS; POTTER, B; ARAMENDIA, P; LEROUX, AE; BIONDI, RM

ONE KINASE, MULTIPLE CONFORMATIONS: PROBING THE CONFORMATIONAL LANDSCAPE OF PDK1 WITH SMALL MOLECULES

LVI Reunión Científica anual SAIB y XV de SAMIGE

Lugar: Mendoza; Año: 2020;

SACERDOTI, M; GROSS, LZF; GHODE, A; HICKS, KG; RUTTER, J; ANAND, GS; LEROUX, AE; BIONDI, RM

REGULATION OF PDK1 KINASE BY SMALL MOLECULES AND METABOLITES: BIDIRECTIONAL ALLOSTERY AND BEYOND

Translational Chemical Biology

Año: 2020;

GROSS, LZF; SACERDOTI, M; LEROUX, AE; HICKS, KG; RUTTER, J; GRAEWERT, MA; SVERGUN, DI ; GHODE, A; ANAND, GS; KLINKE, S; BIONDI, RM

SMALL COMPOUNDS AND METABOLITES AS CONFORMATIONAL MODULATORS OF FULL-LENGTH PDK1

LVI Reunión Científica anual SAIB y XV de SAMIGE

Lugar: Mendoza; Año: 2020;

LEROUX, ALEJANDRO E.; BIONDI, RICARDO M.

INTRACELLULAR AGGREGATION OF A PDK1 SUBSTRATE BY BLOCKING THE CONFORMATIONAL SENSOR POCKET ON PDK1

LV Reunión Científica anual SAIB y XIV congreso de PABMB

Lugar: Salta; Año: 2019;

GROSS, LISSY; SACERDOTI, MARIANA; LEROUX, ALEJANDRO E.; CAPPELLARI, MV; ARAMENDIA, PF; GHODE, PF; ANAND, GS; KLINKE, S; BIONDI, RICARDO M.

A CHEMICAL BIOLOGY APPROACH TO UNDERSTAND THE REGULATION OF FULL-LENGTH PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1)

LV Reunión Científica anual SAIB y XIV congreso de PABMB

Lugar: Salta; Año: 2019;

SACERDOTI, MARIANA; FROESE, KARIN; SCHULZE, JÖRG; PASTOR-FLORES, DANIEL; BAUER, ANGELIKA; HERBRAND, AMANDA; RILEY, ANDREW; CZIER, GYLES; POTTER, BARRY; SUESS, EVELYN; GROSS, LISSY; LEROUX, ALEJANDRO E.; BIONDI, RICARDO M.

UNDERSTANDING PROTEIN KINASE PDK1 REGULATION USING SMALL MOLECULES TARGETING DIFFERENT SITES

LV Reunión Científica anual SAIB y XIV congreso de PABMB

Lugar: Salta; Año: 2019;

LEROUX, ALEJANDRO E.; BIONDI, RICARDO M.

Identification of regulatory proteins in conformational disorders

Frontiers in Bioscience 3

Lugar: Ciudad autonoma de Buenos aires; Año: 2018;

LEROUX, ALEJANDRO E.; BIONDI, RICARDO M.

Identification of regulatory proteins in conformational disorders

South American Spring Symposium in Signal Transduction and Molecular Medicine 2018

Lugar: Bariloche; Año: 2018;

SACERDOTI, MARIANA; FROESE, KARIN; SCHULZE, JÖRG; PASTOR-FLORES, DANIEL; BAUER, ANGELIKA; HERBRAND, AMANDA; RILEY, ANDREW; CZIER, GYLES; POTTER, BARRY; SUESS, EVELYN; GROSS, LISSY; LEROUX, ALEJANDRO E.; BIONDI, RICARDO M.

Is PDK1 regulated by dimerization?

South American Spring Symposium in Signal Transduction and Molecular Medicine 2018

Lugar: Bariloche; Año: 2018;

GROSS, LISSY; SUESS, EVELYN; SACERDOTI, MARIANA; BARRIO REAL, LAURA; KAZANIETZ, MARCELO; LEROUX, ALEJANDRO E.; BIONDI, RICARDO M.

Can small compounds modulate the mechanism of regulation of novel and atypical PKCs?

South American Spring Symposium in Signal Transduction and Molecular Medicine 2018

Lugar: Bariloche; Año: 2018;

LEROUX, ALEJANDRO E.; BIONDI, RICARDO M.

Identification of regulatory proteins in neurodegenerative and metabolic diseases

Frontiers in Bioscience 2

Lugar: Buenos Aires; Año: 2016;

LEROUX, ALEJANDRO E.; KRAUTH-SIEGEL, R. LUISE

Characterization of an unusual thioredoxin-type protein in African trypanosomes.

Dynamics of Thiol-based Redox Switches in Cellular Physiology

Lugar: Heidelberg; Año: 2014;

LEROUX, ALEJANDRO E.; KRAUTH-SIEGEL, R. LUISE

Characterization of an unusual thioredoxin-type protein in African trypanosomes.

Thiol-Based Redox Regulation & Signaling

Lugar: Girona; Año: 2014;

LEROUX, ALEJANDRO E.; HAANSTRA, J. R.; BAKKER, B. M.; KRAUTH-SIEGEL, R. LUISE

Kinetic analysis and computational modelling of Trypanosoma brucei trypanothione synthetase

6th International Beilstein Symposium

Lugar: Ruedesheim/Rhein; Año: 2013;

LEROUX, ALEJANDRO E.; HAANSTRA, J. R.; BAKKER, B. M.; KRAUTH-SIEGEL, R. LUISE

Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modellin

International Symposium of the German Society for Biochemistry and Molecular Biology (GBM)

Lugar: Frankfurt am Main; Año: 2013;

ACHCAR, F.; LEROUX, ALEJANDRO E.

The Silicotryp consortium: Progress and Perspectives

Final Conference SysMo

Lugar: Berlin; Año: 2013;

LEROUX, ALEJANDRO E.; KRAUTH-SIEGEL, R. LUISE

Analysis of the unique trypanothione metabolism in the framework of the Silicon Trypanosome project

Tropical Medicine and Parasitology - 25th Annual Meeting German Society for Parasitology

Lugar: Heidelberg; Año: 2012;

LEROUX, ALEJANDRO E.; HAANSTRA, J. R.; BAKKER, B. M.; KRAUTH-SIEGEL, R. LUISE

Dissecting the catalytic mechanism of T. brucei trypanothione synthetase by kinetic analysis and computational modelling

44th Microsymposium on Parasite/Trypanosomatid metabolism, drug design and glycosome

Lugar: Amsterdam; Año: 2012;

LEROUX, ALEJANDRO E.; FADDA, A.; ROJAS, F.; MANFUL, T.; FARBER, V.; MATTHEWS, K.R.; KRAUTH-SIEGEL, R. LUISE; CLAYTON, C.

Trypanosome transcriptome dynamics and the kinetics of redox pathway enzymes under pseudo-physiological conditions

6th SysMO Conference

Lugar: Tenerife; Año: 2012;

LEROUX, ALEJANDRO E.; KRAUTH-SIEGEL, R. LUISE

Analysis of the unique trypanothione redox metabolism under pseudo-physiological conditions.

Conference on Glutathione and Related Thiols in Living Cells

Lugar: Sant Feliu de Guixols; Año: 2011;

LEROUX, ALEJANDRO E.; KRAUTH-SIEGEL, R. LUISE

The unique trypanothione redox metabolism in the framework of the Silicon Trypanosome project.

International Conference on Systems Biology

Lugar: Mannheim; Año: 2011;

LEROUX, ALEJANDRO E.; KRAUTH-SIEGEL, R. LUISE

The silicon trypanosome: a system biology approach to improve drug target selection in African trypanosome

12th Drug Design & Development Seminar

Lugar: Heidelberg; Año: 2011;

LEROUX, ALEJANDRO E.; NOWICKI, CRISTINA

Caracterización funcional de enzimas vinculadas a la regeneración de NADPH en tripanosomátidos

XXIII Reunión Científica Anual Sociedad Argentina de Protozoología

Lugar: Santa Fé; Año: 2009;

LEROUX, ALEJANDRO E.; MAUGERI, DANTE; CAZZULO, JUAN JOSÉ; NOWICKI, CRISTINA

Functional characterization of a cytosolic NADP-dependent Isocitrate Dehydrogenase in Trypanosoma cruzi

VIII Congreso Argentino de Protozoología y Enfermedades Parasitarias

Lugar: Rosario, Santa Fe, Argentina; Año: 2008;

LEROUX, ALEJANDRO E.; NOWICKI, CRISTINA

Clonado y caracterización bioquímica de la enzima málica de Leishmania major.

XXII Reunión de la Sociedad Argentina de Protozoología

Lugar: Chascomús; Año: 2007;

LEROUX, ALEJANDRO E.; NOWICKI, CRISTINA

The two Malic isozymes of Trypanosoma brucei are expressed along the whole life cycle of parasite.

XLII Reunión Científica anual SAIB

Lugar: Rosario; Año: 2006;

LEROUX, ALEJANDRO E.; FLEMING-CÁNEPA, XIMENA; ARANDA, ALEJANDRO; MAUGERI, DANTE; CAZZULO, JUAN JOSÉ; SÁNCHEZ, MARCO; NOWICKI, CRISTINA

Functional, molecular characterisation and subcelullar localization of the three malate dehydrogenase (MDH) isozymes in Leishmania species

VII Congreso Argentino de Protozoología y Enfermedades Parasitarias (SAP2005)

Lugar: Mendoza; Año: 2005;

FLEMING-CÁNEPA, X.; LEROUX, ALEJANDRO E.; ARANDA, A.; CAZZULO, JUAN JOSE; NOWICKI CRISTINA

Cloning and biochemical characterization of three different malate dehydrogenase (mdh) isozymes from Leishmania major.

XL Reunión Científica anual SAIB

Lugar: Puerto Iguazú; Año: 2004;

ARANDA, ALEJANDRO; LEROUX, ALEJANDRO E.; CAZZULO, JUAN JOSÉ; NOWICKI, CRISTINA

Cloning and expression of a plausible cytosolic type malate dehydrogenase (cMDH) from Leishmania mexicana

XXXIX Reunion Cientifica anual SAIB

Lugar: San Carlos de Bariloche; Año: 2003;