INVESTIGADORES
MARTIN Mauricio Gerardo
artículos
Título:
Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging.
Autor/es:
ALEJANDRO SODERO; LAURA TROVÓ; FRANCESCA IANNILLI; PAUL VAN VELDHOVEN; CARLOS DOTTI; MAURICIO G MARTIN
Revista:
JOURNAL OF NEUROCHEMISTRY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2011 vol. 116 p. 747 - 755
ISSN:
0022-3042
Resumen:
It is well established that memory formation and retention involve the
coordinated flow of information from the post-synaptic site of
particular neuronal populations to the nucleus, where short and
long-lasting modifications of gene expression occur. With age, mnemonic,
motor and sensorial alterations occur, and it is believed that extra
failures in the mechanisms used for memory formation and storage are the
cause of neurodegenerative pathologies like Alzheimer's disease. A
prime candidate responsible for damage and loss of function during aging
is the accumulation of reactive oxygen species, derived from normal
oxidative metabolism. However, dysfunction in the aged brain is not
paralleled by an increase in neuronal death, indicative that the brain
is better suited to fight against the death signals generated from
reactive oxygen species than against loss-of-function stimuli. A main
aim of this laboratory is to understand how neurons perform and survive
in the constitutive stress background represented by aging. In this
report, we summarize our recent findings in relation to survival.