INVESTIGADORES
MARTIN Mauricio Gerardo
artículos
Título:
Brain cholesterol in normal and pathological aging
Autor/es:
MAURICIO MARTIN; CARLOS DOTTI; MARÍA DOLORES LEDESMA
Revista:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2010 vol. 1801 p. 934 - 944
ISSN:
1388-1981
Resumen:
Correct lipid homeostasis at the plasma membrane is essential for cell
survival and performance. These are critically challenged in the aging
brain. Changes in the levels of cholesterol, a major membrane component
especially enriched in neurons, accompany the brain aging process. They
also occur in neurodegenerative diseases. Understanding the causes and
consequences of these changes is a crucial step when trying to delay the
cognitive decline, which comes with age, or to design strategies to
fight neurodegenerative disorders such as Alzheimer's disease. We here
review work that has contributed to this understanding.
