ILEX PARAGUARIENSIS EXTRACT IMPROVES BIOCHEMICAL PARAMETERS IN OLD MICE: AN IN VIVO STUDY

MARIA ROSANA RAMIREZ; VALERIA GRISELDA CEREVIN ; ADRIANE JORAS MACHADO ; IGNACIO RINTOUL

Congreso; Reunion anual de sociedades de biociencias; 2020

SAIC

Tea from Ilex paraguariensis (IP) is widely available and is a good source of caffeine and other bioactive compounds. The genus Ilex, are also traditional drinks, with lesser overall usage, but have attracted much recent attention and have been subjected to further study. Because the potential of IP has been suggested in the management of obesity, the aim of the present study was to evaluate the putative effect of IP extract on weight loss, biochemical parameters in old obese mice. Thirty animals were randomly assigned to three groups according to the treatment (water or IP extract 1.0 g/kg body weight). The roasted IP extract was prepared according Pharmacopoeia, and administrated by intragastric gavage. The experiments were performed in accordance with the principles for animal experimentation. After treatment intervention (30 days), plasma concentrations of total cholesterol, high-density lipoprotein colesterol (HDL), triglyceride, and glucose were evaluated using WienerLab kits (Rosario, Argentina). Plasma LDL cholesterol concentration was calculated according to the formula: CHOL−(triglyceride/5 + high-density lipoprotein. Comparisons among groups of data were done using one-way ANOVA followed by the Dunnett Multiple Comparisons test. An associated probability (P value) of