MARIÑO, KARINA V.; CAGNONI, ALEJANDRO J.; CROCI, DIEGO O.; RABINOVICH, GABRIEL A.

Targeting galectin-driven regulatory circuits in cancer and fibrosis

NATURE REVIEWS DRUG DISCOVERY; Año: 2023

BANNOUD, NADIA; STUPIRSKI, JUAN C.; CAGNONI, ALEJANDRO J.; HOCKL, PABLO F.; PÉREZ SÁEZ, JUAN M.; GARCÍA, P. ALFREDO; MAHMOUD, YAMIL D.; TUDELA, JULIÁN GAMBARTE; SCHEIDEGGER, MARCO A.; MARSHALL, ANDREA; CORRIE, PIPPA G.; MIDDLETON, MARK R.; MARIÑO, KARINA V.; GIROTTI, M. ROMINA; CROCI, DIEGO O.; RABINOVICH, GABRIEL A.

Circulating galectin-1 delineates response to bevacizumab in melanoma patients and reprograms endothelial cell biology

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2023 vol. 120

RUBIONE, JULIA; PÉREZ, PAULA S.; CZERNIKIER, ALEJANDRO; DUETTE, GABRIEL A.; GERBER, FEDERICO PEHUEN PEREYRA; SALIDO, JIMENA; FABIANO, MARTINA P.; GHIGLIONE, YANINA; TURK, GABRIELA; LAUFER, NATALIA; CAGNONI, ALEJANDRO J.; PÉREZ SÁEZ, JUAN M.; MERLO, JOAQUÍN P.; PASCUALE, CARLA; STUPIRSKI, JUAN C.; SUED, OMAR; VARAS-GODOY, MANUEL; LEWIN, SHARON R.; MARIÑO, KARINA V.; RABINOVICH, GABRIEL A.; OSTROWSKI, MATÍAS

A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

mBio; Año: 2022 vol. 13

CANO, MARÍA EMILIA; JARA, WALTER EMILIANO; CAGNONI, ALEJANDRO J.; BRIZZIO, EMMANUEL; STRUMIA, MIRIAM C.; REPETTO, EVANGELINA; UHRIG, MARÍA LAURA

The disulfide bond as a key motif for the construction of multivalent glycoclusters

NEW JOURNAL OF CHEMISTRY; Año: 2022 vol. 46 p. 17682 - 17695

DA COSTA, VALERIA ; VAN VLIET, SANDRA J.; FRIGERIO, SOFÍA; GARCÍA, PABLO A.; CROCI, DIEGO O.; FESTARI, MARÍA FLORENCIA; COSTA, MONIQUE; LANDEIRA, MERCEDES; RODRÍGUEZ-ZRAQUIA, SANTIAGO A.; CAGNONI, ALEJANDRO J.; CUTINE, ANABELA; RABINOVICH, GABRIEL A.; OSINAGA, EDUARDO; MARIÑO, KARINA V.; FREIRE, TERESA

The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2)

CANCER LETTERS; Lugar: Ireland; Año: 2021 vol. 518 p. 72 - 81

MANSELLE COCCO, MONTANA; VEIGAS, FLORENCIA; BACH, CAMILA A.; BLIDNER, ADA G.; CAGNONI, ALEJANDO J.; DALOTTO MORENO, TOMÁS; HOCKL, PABLO F.; MAHMOUD, YAMIL; SCHEIDEGGER, MARCO; SIRINO, ALICIA; TORRES, NICOLAS; WIERSBA, VALERIA; RABINOVICH, GABRIEL A.

COVID-T: A functional platform to monitor SARS-CoV-2-specific T cell responses in vaccinated individuals and COVID-19 recovered patients

MEDICINA (BUENOS AIRES); Lugar: Buenos Aires; Año: 2021

CECILIA PORCIUNCULA; CAGNONI, ALEJANDRO J.; FONTANA, CAROLINA; MARIÑO, KARINA V.; PATRICIA SAENZ-MENDEZ; CECILIA GIACOMINI; GABRIELA IRAZOQUI

Structural insights in galectin-1-glycan recognition: relevance of the glycosidic linkage and the N-acetylation pattern of sugar moieties

BIOORGANIC & MEDICINAL CHEMISTRY.; Lugar: Amsterdam; Año: 2021

ALEJANDRO J. CAGNONI; GIRIBALDI, LAURA; BLIDNER, ADA G.; CUTINE, ANABELA; GATTO, SABRINA G.; MORALES, ROSA; SALATINO, MARIANA; ABBA, MARTÍN; CROCI, DIEGO O.; MARIÑO, KARINA V.; RABINOVICH, GABRIEL A.

Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8+ regulatory T cells

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2021

LUCIANO MOROSI; CUTINE, ANABELA; ALEJANDRO J. CAGNONI; MANSELLE COCCO, MONTANA; CROCI, DIEGO O.; MORALES, ROSA; MAY, MARÍA; MENDEZ-HUERGO, SANTIAGO; PUCCI, BETINA; GIL, A. H.; HORNOS, S. P.; DOCENA, GUILLERMO H.; SAMBUELLI, ALICIA M.; TOSCANO, MARTA; RABINOVICH, GABRIEL A.; MARIÑO, KARINA V.

Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits

Science Advances; Año: 2021

MALLER, SEBASTIÁN M.; CAGNONI, ALEJANDRO J.; BANNOUD, NADIA; SIGAUT, LORENA; PÉREZ SÁEZ, JUAN M.; PIETRASANTA, LÍA I.; YANG, RI-YAO; LIU, FU-TONG; CROCI, DIEGO O.; DI LELLA, SANTIAGO; SUNDBLAD, VICTORIA; RABINOVICH, GABRIEL A.; MARIÑO, KARINA V.

An adipose tissue galectin controls endothelial cell function via preferential recognition of 3‐fucosylated glycans

FASEB JOURNAL; Año: 2020 vol. 34 p. 735 - 753

CAGNONI, ALEJANDRO J.; PRIMO, EMILIANO D.; KLINKE, SEBASTIÁN; CANO, MARÍA E.; GIORDANO, WALTER; MARIÑO, KARINA V.; KOVENSKY, JOSÉ; GOLDBAUM, FERNANDO A.; UHRIG, MARÍA LAURA; OTERO, LISANDRO H.

Crystal structures of peanut lectin in the presence of synthetic β-N- and β-S-galactosides disclose evidence for the recognition of different glycomimetic ligands

Acta Crystallographica Section D Structural Biology; Año: 2020 vol. 76 p. 1080 - 1091

CRISTÓFALO, ALEJANDRO E.; CAGNONI, ALEJANDRO J.; UHRIG, MARÍA LAURA

Synthesis of: N -acetylglucosamine and N -acetylallosamine resorcinarene-based multivalent β-thio-glycoclusters: Unexpected affinity of N -acetylallosamine ligands towards Wheat Germ Agglutinin

ORGANIC & BIOMOLECULAR CHEMISTRY; Año: 2020 vol. 18 p. 6853 - 6865

PÉREZ SÁEZ, JUAN M.; HOCKL, PABLO F.; CAGNONI, ALEJANDO J.; MÉNDEZ HUERGO, SANTIAGO P.; GARCÍA, PABLO A.; GATTO, SABRINA G.; CERLIANI, JUAN P.; CROCI, DIEGO O.; RABINOVICH, GABRIEL A.

Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities

ANGIOGENESIS; Año: 2020

CAGNONI, ALEJANDRO J.; MARÍA FERNANDA TRONCOSO; RABINOVICH, GABRIEL A.; MARIÑO, KARINA V.; MARIA TERESA ELOLA

Full-length Galectin-8 and separate carbohydrate recognition domains: the whole is greater than the sum of its parts?

BIOCHEMICAL SOCIETY TRANSACTIONS; Lugar: Londres; Año: 2020

CECILIA PORCIUNCULA; ALEJANDRO J. CAGNONI; MARIÑO, KARINA V.; CAROLINA FONTANA; PATRICIA SAENZ-MENDEZ; GABRIELA IRAZOQUI; CECILIA GIACOMINI

Enzymatic synthesis of non-natural trisaccharides and galactosides; Insights of their interaction with galectins as a function of their structure

CARBOHYDRATE RESEARCH; Lugar: Amsterdam; Año: 2019 vol. 472

FÁTIMA FERRAGUT; ALEJANDRO J. CAGNONI; LUCAS COLOMBO; CLARA SANCHEZ TERRERO; CARLOTA WOLFESTEIN-TODEL; MARÍA FERNANDA TRONCOSO; SILVIA I VANZULLI; RABINOVICH, GABRIEL ADRIÁN; KARINA MARIÑO; MARIA TERESA ELOLA

Dual knockdown of Galectin-8 and its glycosylated ligand, the activated leukocyte cell adhesion molecule (ALCAM/CD166), synergistically delays in vivo breast cancer growth

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH; Lugar: Amsterdam; Año: 2019

LUJÁN, AGUSTÍN L.; CROCI, DIEGO O.; GAMBARTE TUDELA, JULIAN A.; LOSINNO, ANTONELLA D.; CAGNONI, ALEJANDRO J.; MARIÑO, KARINA V.; DAMIANI, MARÍA T.; RABINOVICH, GABRIEL A.

Glycosylation-dependent galectin-receptor interactions promote Chlamydia trachomatis infection

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2018

MARISA M. FERNÁNDEZ; FÁTIMA FERRAGUT; VICTOR M. CÁRDENAS DELGADO; CANDELARIA BRACALENTE; ALICIA I BRAVO; ALEJANDRO J. CAGNONI; MYRIAM NÚÑEZ; LUCIANO MOROSI; HECTOR R QUINTA; MARÍA V ESPELT; MARÍA FERNANDA TRONCOSO; CARLOTA WOLFESTEIN-TODEL; MARIÑO, KARINA V.; EMILIO MAICHIODI; RABINOVICH, GABRIEL ADRIÁN; MARIA TERESA ELOLA

Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS; Lugar: Amsterdam; Año: 2016

ALEJANDRO J. CAGNONI; JUAN MANUEL PÉREZ SÁEZ; RABINOVICH, GABRIEL ADRIÁN; KARINA MARIÑO

Turning-off Signaling by Siglecs, Selectins and Galectins: Chemical Inhibition of Glycan-dependent Interactions in Cancer

Frontiers in Oncology; Año: 2016

AGUSTI, ROSALÍA; CANO, MARÍA EMILIA; ALEJANDRO J. CAGNONI; JOSÉ KOVENSKY; LEDERKREMER, ROSA; MARÍA LAURA UHRIG

Multivalent sialylation of β-thio- glycoclusters by Trypanosoma cruzi trans sialidase and analysis by high performance anion exchange chromatography

GLYCOCONJUGATE JOURNAL; Lugar: Berlin; Año: 2016

BLIDNER, ADA G.; MÉNDEZ-HUERGO, SANTIAGO P.; CAGNONI, ALEJANDRO J. ; RABINOVICH, GABRIEL A.

Re-wiring regulatory cell networks in immunity by galectin-glycan interactions

FEBS LETTERS; Lugar: Amsterdam; Año: 2015 vol. 589 p. 3407 - 3418

ALEJANDRO J. CAGNONI; JOSÉ KOVENSKY; MARÍA LAURA UHRIG

Design and Synthesis of Hydrolytically Stable Multivalent Ligands Bearing Thiodigalactoside Analogues for Peanut Lectin and Human Galectin-3 Binding

JOURNAL OF ORGANIC CHEMISTRY; Lugar: Washington; Año: 2014 vol. 79 p. 6456 - 6467

CANO, MARÍA EMILIA; AGUSTI, ROSALÍA; CAGNONI, ALEJANDRO JAVIER; TESORIERO, MARÍA FLORENCIA; KOVENSKY, JOSÉ; MARÍA LAURA UHRIG; LEDERKREMER, ROSA

Synthesis of divalent ligands of b-thio- and b-N-galactopyranosides and related lactosides and their evaluation as substrates and inhibitors of Trypanosoma cruzi trans-sialidase

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY; Año: 2014 vol. 10 p. 3073 - 3086

CAGNONI, ALEJANDRO JAVIER; VARELA, OSCAR; MARÍA LAURA UHRIG; KOVENSKY, JOSÉ

Efficient Synthesis of Thiolactoside Glycoclusters by Ruthenium-Catalyzed Cycloaddition Reaction of Disubstituted Alkynes on Carbohydrate Scaffolds

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; Lugar: Weinheim; Año: 2013 p. 972 - 983

ALEJANDRO J. CAGNONI; OSCAR VARELA; JOSÉ KOVENSKY

Synthesis and biological activity of divalent ligands based on 3-deoxy-4-thiolactose, an isosteric analogue of lactose

ORGANIC & BIOMOLECULAR CHEMISTRY; Lugar: Cambridge; Año: 2013 vol. 11 p. 5500 - 5511

LUIS CALLE; VIRGINIA ROLDÓS; JAVIER CAÑADA; MARÍA LAURA UHRIG; CAGNONI, ALEJANDRO JAVIER; MANZANO, VERÓNICA; OSCAR VARELA; JIMENEZ-BARBERO, JESÚS

Escherichia coli beta-Galactosidase Inhibitors through Modifications at the Aglyconic Moiety: Experimental Evidence of Conformational Distortion in the Molecular Recognition

Chemistry - A european journal; Lugar: Weinheim; Año: 2013 vol. 19 p. 4262 - 4270

CAGNONI, ALEJANDRO JAVIER; O. VARELA; S.G. GOUIN; JOSÉ KOVESNKY; MARÍA LAURA UHRIG

Synthesis of Multivalent Glycoclusters from 1-Thio-b-D-galactose and Their Inhibitory Activity against the b-Galactosidase from E. coli

JOURNAL OF ORGANIC CHEMISTRY; Lugar: Washington; Año: 2011 vol. 76 p. 3064 - 3077

ALEJANDRO J. CAGNONI; MARÍA LAURA UHRIG; OSCAR VARELA

Synthesis of pentopyranosyl-containing thiodisaccharides. Inhibitory activity against b-glycosidases

BIOORGANIC & MEDICINAL CHEMISTRY.; Lugar: Amsterdam; Año: 2009 vol. 17 p. 6203 - 6212