Multi-beta-S- and bera-N-galacto- and lactosides as substrates and inhibitors of T. cruzi trans-sialidase

ROSALÍA AGUSTÍ; MARÍA EMILIA CANO; MARÍA FLORENCIA TESORIERO; MARÍA LAURA UHRIG; ROSA M. DE LEDERKREMER

Buenos Aires

Simposio; 1er Simposio Argentino de Glicobiología - GLYCOAR 2014; 2014

IBYME

Trypanosoma cruzi, the agent of Chagas disease, does not synthesize sialic acid de novo. A parasite trans-sialidase (TcTS) activity transfers sialic acid from host glycoconjugates to terminal beta-galactopyranosyl groups in acceptor parasite substrates. TcTS probed to be essential for the parasite survival. We have previously determined that lactose analogs are inhibitors of this enzyme and that conjugation with multiarm polyethyleneglycol enhances their bioavailability in vivo. We hereby present the acceptor properties of a family of multivalent compounds bearing beta-S- or beta-N-galactose and lactose residues linked to sugar scaffolds.