Effect of lactic acid bacteria on immune-metabolic parameters and intestinal microbiota composition in an obesity murine model

FABERSANI, EMANUEL; ROSS GLORIA R.,; GAUFFIN CANO,M. P

Simposio; V Simposio Internacional de Bacterias Lácticas (SIBAL). Benefitting from lactic acid bacteria. Progress in health and food; 2016

CERELA

Currently, obesity and its harmful comorbidities (type 2diabetes, cancer, cardiovascular and respiratory diseases) are a major global public health concern, mainly due to the fact that the prevalence of these disorders is drastically increasing over time. So far, the underlying mechanisms involved in the development of these disorders have not been fully elucidated. However, it has been well established that three main factors (diet, genetics and intestinal microbiota) interact amog them and establish the immune-metabolic profile that in turn determinates the health and disease status of the host. In this context, strategies that seek to reduce immune-metabolic disorders associated with alteration of gut microbiota are crucial. Our aim was to evaluate the effect of two potential beneficial lactic acid bacteria (LAB) with different immunomodulatory capacity on metabolic and immunological parameters and on the composition of intestinal microbiota in a model of obesity induced by a high-fat diet (HFD)