MARIANA MALVICINI; MAYSA SILVEIRA VILBERT; JOSE NICOLAS MINATTA; VALERIA COLOMO COSTAS; MANGLIO RIZZO

Optimal Therapeutic Strategy for PD-L1 Negative Metastatic Non-Small Cell Lung Cancer: A Decision-Making Guide Based on Clinicopathological and Molecular Features

CURRENT TREATMENT OPTIONS IN ONCOLOGY; Lugar: Berlin; Año: 2023

GISELA WEIZ; MOLEJON MARIA INES; MARIANA MALVICINI; CAECILIA SUKOWATI; CLAUDIO TIRIBELLI; GUILLERMO MAZZOLINI; JAVIER BRECCIA

Glycosylated 4-methylumbelliferone as a targeted therapy for hepatocellular carcinoma

LIVER INTERNATIONAL; Lugar: Londres; Año: 2022

GAYET PREISS, FERNANDO; PICCIONI, FLAVIA; FUSCO, MARIEL; DÍAZ GUTIERREZ, MARCO AURELIO; RIBATTO, PAMELA; BAYO, JUAN; RIZZO, MANGLIO; MALVICINI, MARIANA

La modulación de la expresión de ácido hialurónico reduce la resistencia a la quimioterapia de células iniciadoras de tumor en cáncer de pulmón experimental

Oncología Clínica; Año: 2022 vol. 27

RODRÍGUEZ, MARCELO M.; ONORATO, AGOSTINA; CANTERO, MARÍA JOSÉ; DOMÍNGUEZ, LUCIANA; BAYO, JUAN; FIORE, ESTEBAN; GARCÍA, MARIANA; ATORRASAGASTI, CATALINA; CANBAY, ALI; MALVICINI, MARIANA*; MAZZOLINI, GUILLERMO D. *EQUAL CONTRIBUTION

4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice

Scientific Reports; Año: 2021 vol. 11

GUILLERMO MAZZOLINI; ALEXIS IRACHETA; MARIANA MALVICINI; JUAN BAYO

Immunotherapy for Hepatocellular Carcinoma: Is Latin America Ready for Primetime?

Clinical Liver Disease; Año: 2020

FIORE, ESTEBAN; DOMÍNGUEZ, LUCIANA M.; BAYO, JUAN; MALVICINI, MARIANA; ATORRASAGASTI, CATALINA; RODRIGUEZ, MARCELO; CANTERO, MARÍA JOSÉ; GARCÍA, MARIANA; YANNARELLI, GUSTAVO; MAZZOLINI, GUILLERMO

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

GENE THERAPY; Año: 2020 vol. 27 p. 62 - 73

BAYO, JUAN; FIORE, ESTEBAN J.; DOMINGUEZ, LUCIANA MARÍA; CANTERO, MARÍA JOSE; CIARLANTINI, MATIAS S.; MALVICINI, MARIANA; ATORRASAGASTI, CATALINA; GARCIA, MARIANA GABRIELA; ROSSI, MARIO; CAVASOTTO, CLAUDIO; MARTINEZ, ELISABETH; COMIN, JULIETA; MAZZOLINI, GUILLERMO D.

Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma

GUT - AN INTERNATIONAL JOURNAL OF GASTROENTEOROLOGY AND HEPATOLOGY; Año: 2020

BAYO, JUAN; FIORE, ESTEBAN J.; DOMINGUEZ, LUCIANA M.; REAL, ALEJANDRINA; MALVICINI, MARIANA; RIZZO, MANGLIO; ATORRASAGASTI, CATALINA; GARCÍA, MARIANA G.; ARGEMI, JOSEPMARIA; MARTINEZ, ELISABETH D.; MAZZOLINI, GUILLERMO D.

A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets

JOURNAL OF HEPATOLOGY; Lugar: Amsterdam; Año: 2019

ATORRASAGASTI, CATALINA; ONORATO, AGOSTINA; GIMENO, MARÍA L.; ANDREONE, LUZ; GARCIA, MARIANA; MALVICINI, MARIANA; FIORE, ESTEBAN; BAYO, JUAN; PERONE, MARCELO J.; MAZZOLINI, GUILLERMO D.

SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice

CLINICAL SCIENCE (LONDON, ENGLAND : 1979); Año: 2019 vol. 133 p. 351 - 365

GUILLERMO MAZZOLINI; MARIANA MALVICINI

Immunostimulatory monoclonal antibodies for hepatocellular carcinoma therapy. Trends and perspectives.

MEDICINA (BUENOS AIRES); Lugar: Buenos Aires; Año: 2018

MALVICINI, MARIANA; GUTIERREZ-MORAGA, ANA; RODRIGUEZ, MARCELO M.; GOMEZ-BUSTILLO, SOFIA; SALAZAR, LORENA; SUNKEL, CARLOS; NOZAL, LEONOR; SALGADO, ANTONIO; HIDALGO, MANUEL; LOPEZ-CASAS, PEDRO P.; NOVELLA, JOSE LUIS; VAQUERO, JUAN JOSE; ALVAREZ-BUILLA, JULIO; MORA, ADDA; GIDEKEL, MANUEL; MAZZOLINI, GUILLERMO

"A tricin derivative from Deschampsia antarctica Desv. inhibits colorectal carcinoma growth and liver metastasis through the induction of a specific immune response"

MOLECULAR CANCER THERAPEUTICS; Año: 2018

RODRÍGUEZ, MARCELO M.; FIORE, ESTEBAN; BAYO, JUAN; ATORRASAGASTI, CATALINA; GARCÍA, MARIANA; ONORATO, AGOSTINA; DOMÍNGUEZ, LUCIANA; MALVICINI, MARIANA*; MAZZOLINI, GUILLERMO* (EQUAL CONTRIBUTION)

4Mu Decreases CD47 Expression on Hepatic Cancer Stem Cells and Primes a Potent Antitumor T Cell Response Induced by Interleukin-12

MOLECULAR THERAPY (PRINT); Año: 2018 vol. 26 p. 2738 - 2750

BAYO J; REAL A; FIORE E; MALVICINI M; SGANGA L; BOLONTRADE M; ANDREANI O; BIZAMA C; FRESNO C; PODHAJCER O; FERNANDEZ E; GIDEKEL M; MAZZOLINI G; GARCIA MG

IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness

Oncotarget; Año: 2016

PEIXOTO E; ATORRASAGASTI C; MALVICINI M; FIORE E ; RODRIGUEZ M; GARCIA M; FINOCCHIETO P; PODEROSO JJ; CORRALES F; MAZZOLINI G

SPARC gene deletion protects against toxic liver injury and is associated to an enhanced proliferative capacity and reduced oxidative stress response.

Oncotarget; Lugar: Albany, N.Y.; Año: 2016

ESTEBAN FIORE; MARIANA MALVICINI; JUAN BAYO; ESTANISLAO PEIXOTO; CATALINA ATORRASAGASTI; ROMINA SIERRA; MARCELO MAXIMILIANO RODRIGUEZ; SOFIA GOMEZ BUSTILLO; MARIANA GARCIA; JORGE AQUINO; GUILLERMO MAZZOLINI

Involvement of hepatic macrophages in the antifibrotic effect of IGF-I-overexpressing mesenchymal stromal cells.

Stem Cell Res Ther; Año: 2016

FIORE, E; BAYO J; GARCIA M; MALVICINI M; LLOYD, R; PICCIONI, F; RIZZO, M; PEIXOTO, E; SOLA MB; ATORRASAGASTI C; ALANIZ L; CAMILLETTI MA; ENGUITA, M; PRIETO, J; AQUINO J; MAZZOLINI G

Mesenchymal stromal cells engineered to produce IGF-I by recombinant adenovirus ameliorate liver fibrosis in mice

STEM CELLS AND DEVELOPMENT; Lugar: New York; Año: 2015

PICCIONI F; FIORE E; BAYO J; ATORRASAGASTI, C; PEIXOTO, E; MALVICINI, M; TIRADO-GONZALEZ, I

4-methylumbelliferone inhibits hepatocellular carcinoma growths by decreasing IL-6 production and angiogenesis.

GLYCOBIOLOGY; Lugar: Oxford; Año: 2015

MARIANA MALVICINI; ESTEBAN FIORE; VALENTINA GHIACCIO; FLAVIA PICCIONI; MIGUEL RIZZO; LUCILA OLMEDO BONADEO; MARIANA GARCIA; MARCELO MAXIMILIANO RODRIGUEZ; JUAN BAYO; ESTANISLAO PEIXOTO; CATALINA ATORRASAGASTI; LAURA ALANIZ; JORGE AQUINO; PABLO MATAR; GUILLERMO MAZZOLINI

Tumor Microenvironment Remodeling by 4-Methylumbelliferone Boosts the Antitumor Effect of Combined Immunotherapy in Murine Colorectal Carcinoma.

MOLECULAR THERAPY (PRINT); Lugar: San Diego; Año: 2015

RIZZO M; BAYO. J; PICCIONI F; MALVICINI M; FIORE E; PEIXOTO E; GARCIA M; AQUINO J; GONZALEZ CAMPAÑA A; PODESTÁ G; TERRES M; ANDREANI O; ALANIZ L; MAZZOLINI G

Low molecular weight hyaluronan-pulsed human dendritic cells showed increased migration capacity and induced resistance to tumor chemoattraction

PLOS ONE; Lugar: San Francisco; Año: 2014

MALVICINI M; AQUINO J; MAZZOLINI G

Combined Therapy for Gastrointestinal Carcinomas: Exploiting Synergies Between Gene Therapy and Classical Chemo-Radiotherapy

CURRENT GENE THERAPY; Lugar: Oak Park; Año: 2014

BAYO. J; FIORE. EF; AQUINO, JB; MALVICINI M; RIZZO, M; PEIXOTO E; ALANIZ L; PICCIONI F; BOLONTRADE M

Human umbilical cord perivascular cells exhibited enhanced migration capacity towards hepatocellular carcinoma in comparison with bone marrow mesenchymal stromal cells: a role for autocrine motility factor receptor.

BioMed research international; Año: 2014

BAYO J; AQUINO J; MALVICINI M; RIZZO M; PEIXOTO E; ANDREANI O; ALANIZ L; PICCIONI F; BOLONTRADE M; PODHAJCER O; GARCIA M; MAZZOLINI G

Increased Migration of Human Mesenchymal Stromal Cells by Autocrine Motility Factor (AMF) Resulted in Enhanced Recruitment towards Hepatocellular Carcinoma.

PLOS ONE; Lugar: San Francisco; Año: 2014 vol. 9 p. 95171 - 95181

ATORRASAGASTI, M.1; ; PEIXOTO, E.; AQUINO, J.; KIPPES. N; MALVICINI M; ALANIZ. L; GARCIA. M; PICCIONI. F; FIORE. EF; BAYO. J; BATALLER R,; GURUCEAGA E,; CORRALES F,; PODHAJCER O,; MAZZOLINI G.

Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.

PLOS ONE; Lugar: San Francisco; Año: 2013 vol. 8 p. 54962 - 54963

MARIANA MALVICINI, LAURA ALANIZ, JUAN BAYO, MARIANA GARCÍA, FLAVIA PICCIONI,ESTEBAN FIORE, CATALINA ATORRASAGASTI, JORGE B. AQUINO PABLO MATAR AND GUILLERMO MAZZOLINI

Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice

OncoImmunology; Lugar: Austin, TX; Año: 2012 p. 1038 - 1047

MARIANA MALVICINI, FLAVIA PICCIONI, JUAN BAYO, ESTEBAN FIORE, CATALINA ATORRASAGASTI, LAURA ALANIZ, MARIANA GARCÍA, JORGE B. AQUINO,PABLO MATAR AND GUILLERMO MAZZOLINI; MANUEL GIDEKEL

Chemoimmunotherapy for advanced gastrointestinal carcinomas A successful combination of gene therapy and cyclophosphamide

OncoImunology; Año: 2012

ATORRASAGASTI C, AQUINO JB, HOFMAN L, ALANIZ L, MALVICINI M, GARCIA M, BENEDETTI L, FRIEDMAN SL, PODHAJCER OL, MAZZOLINI GD

SPARC down-regulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-beta1 and PDGF.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY; Año: 2011 vol. 300 p. 739 - 748

MALVICINI M, INGOLOTTI M, PICCIONI F, GARCIA M, BAYO J, ATORRASAGASTI C, ALANIZ L, AQUINO JB, ESPINOZA JA, GIDEKEL M, SCHAROVSKY OG, MATAR P, MAZZOLINI G. SOURCE

Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12

MOLECULAR ONCOLOGY; Año: 2011 vol. 5 p. 242 - 255

GARCIA MG, BAYO J, BOLONTRADE MF, SGANGA L, MALVICINI M, ALANIZ L, AQUINO JB, FIORE E, RIZZO MM, RODRIGUEZ A, LORENTI A, ANDRIANI O, PODHAJCER O, MAZZOLINI G

Hepatocellular Carcinoma Cells and Their Fibrotic Microenvironment Modulate Bone Marrow-Derived Mesenchymal Stromal Cell Migration in Vitro and in Vivo

MOLECULAR PHARMACOLOGY; Año: 2011 p. 1538 - 1548

ALANIZ L, RIZZO M, GARCIA MG, PICCIONI F, AQUINO JB, MALVICINI M, ATORRASAGASTI C, BAYO J, ECHEVERRIA I, SAROBE P, MAZZOLINI G.

Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases their migratory ability and induces immunity against murine colorectal carcinoma.

CANCER IMMUNOLOGY IMMUNOTHERAPY; Año: 2011 p. 1 - 13

PICCIONI F, MALVICINI M, GARCIA MG, RODRIGUEZ A, ATORRASAGASTI C, KIPPES N, BUENA IT, RIZZO MM, BAYO J, AQUINO J, VIOLA M, PASSI A, ALANIZ L, MAZZOLINI G.

Antitumor effects of hyaluronic acid inhibitor 4-Methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice.

GLYCOBIOLOGY; Año: 2011

MALVICINI M, PUCHULO G, MATAR P, MAZZOLINI G.

INMUNOTERAPIA DEL CÁNCER. IMPORTANCIA DE CONTROLAR LA INMUNOSUPRESIÓN.

MEDICINA-BUENOS AIRES; Año: 2010 vol. 70 p. 565 - 570

MARIANA MALVICINI, MIGUEL RIZZO, LAURA ALANIZ, FEDERICO PIÑERO, MARIANA GARCÍA, CATALINA ATORRASAGASTI, JORGE B. AQUINO, VIVIANA ROZADOS,O. GRACIELA SCHAROVSKY,PABLO MATAR, GUILLERMO MAZZOLINI

A Novel Synergistic Combination of Cyclophosphamide and Gene Transfer of Interleukin-12 Eradicates Colorectal Carcinoma in Mice

CLINICAL CANCER RESEARCH; Año: 2009 vol. 15 p. 7256 - 7265

ALANIZ L, RIZZO M, MALVICINI M, JAUNARENA J, AVELLA D, ATORRASAGASTI C, AQUINO JB, GARCIA M, MATAR P, SILVA M, MAZZOLINI G.

Low molecular weight hyaluronan inhibits colorectal carcinoma growth by decreasing tumor cell proliferation and stimulating immune response

CANCER LETTERS; Año: 2009 vol. 278 p. 9 - 16

ATORRASAGASTI C, MALVICINI M, AQUINO JB, ALANIZ L, GARCIA M, BOLONTRADE M, RIZZO M, PODHAJCER OL, MAZZOLINI G.

Overexpression of SPARC obliterates the in vivo tumorigenicity of human hepatocellular carcinoma cells.

INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER.; Año: 2009 vol. 126 p. 2726 - 2740

MATAR P, ALANIZ L, ROZADOS V, AQUINO JB, MALVICINI M, ATORRASAGASTI C,, MAZZOLINI G

IMMUNOTHERAPY FOR LIVER TUMORS: PRESENT STATUS AND FUTURE PROSPECTS.

JOURNAL OF BIOMEDICAL SCIENCE; Año: 2009 p. 16 - 30