INVESTIGADORES
FERNANDEZ Ariel
artículos
Título:
Making Targeted Therapy Compatible with Checkpoint Immunotherapy
Autor/es:
FERNÁNDEZ, ARIEL
Revista:
TRENDS IN BIOTECHNOLOGY
Editorial:
ELSEVIER SCIENCE LONDON
Referencias:
Año: 2017 vol. 35 p. 582 - 584
ISSN:
0167-7799
Resumen:
Immune checkpoint blockades induced by antibodies are revolutionizing cancer therapy. Combinations of checkpoint immunotherapies with kinase inhibitors (KIs) are being clinically evaluated as oncogenic mutations arise. Off-target KI cross-reactivity will often compromise synergistic efficacy, with KIs suppressing T-cell functionalities that checkpoint blockers are purportedly boosting. This incompatibility may be removed through molecular optimization.
