INVESTIGADORES
FERNANDEZ Ariel
artículos
ARIEL FERNANDEZ; RIDGWAY SCOTT
Advanced modeling reconciles counterintuitive decisions in lead optimization
TRENDS IN BIOTECHNOLOGY; Lugar: Londres; Año: 2017 vol. 30 p. 490 - 497
ARIEL FERNANDEZ; RIDGWAY SCOTT
Drug leads for interactive protein targets with unknown structure
DRUG DISCOVERY TODAY; Lugar: Amsterdam; Año: 2016 vol. 21 p. 531 - 535
ARIEL FERNANDEZ
Acid-base chemistry of frustrated water at protein interfaces
FEBS LETTERS; Lugar: Amsterdam; Año: 2016 vol. 590 p. 215 - 223
ARIEL FERNANDEZ
Non-Debye frustrated hydration steers biomolecular association: interfacial tension for the drug designer
FEBS LETTERS; Lugar: Amsterdam; Año: 2016 vol. 590 p. 3481 - 3491
ARIEL FERNANDEZ
Packing defects functionalize soluble proteins
FEBS LETTERS; Lugar: Amsterdam; Año: 2015 vol. 589 p. 967 - 973
ARIEL FERNANDEZ
Quantum theory of interfacial tension quantitatively predicts spontaneous charging of nonpolar aqueous interfaces
PHYSICS LETTERS A; Lugar: Amsterdam; Año: 2015 vol. 379 p. 2405 - 2408
MARIA EUGENIA INDA ; MICHEL VANDENBRANDEN; ARIEL FERNANDEZ ; DIEGO DE MENDOZA; JEAN-MARIE RUYSSCHAERT; LARISA ESTEFANIA CYBULSKI
A lipid-mediated conformational switch modulates the thermosensing activity of DesK
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2014 vol. 111 p. 3579 - 3584
ARIEL FERNANDEZ
Water promotes the sealing of nanoscale packing defects in folding proteins
JOURNAL OF PHYSICS CONDENSED MATTER; Lugar: Londres; Año: 2014 vol. 26 p. 202101 - 202101
ARIEL FERNANDEZ
Communication: Chemical functionality of interfacial water enveloping nanoscale structural defects in proteins
JOURNAL OF CHEMICAL PHYSICS; Lugar: New York; Año: 2014 vol. 140 p. 221102 - 221102
JOAN MONTES DE OCA; ARIEL RODRIGUEZ-FRIS; GUSTAVO APPIGNANESI; ARIEL FERNANDEZ
Productive induced metastability in allosteric modulation of kinase function
FEBS JOURNAL; Lugar: Londres; Año: 2014 vol. 281 p. 3079 - 3091
ARIEL FERNANDEZ
Synergizing immunotherapy with molecularly targeted anticancer treatment
DRUG DISCOVERY TODAY; Lugar: Amsterdam; Año: 2014 vol. 19 p. 1427 - 1432
ARIEL FERNANDEZ
Breakdown of the Debye polarization ansatz at protein-water interfaces
JOURNAL OF CHEMICAL PHYSICS; Lugar: New York; Año: 2013 vol. 138 p. 225103 - 225103
ARIEL FERNANDEZ
Supramolecular evolution of protein organization
ANNUAL REVIEW OF GENETICS; Lugar: Palo Alto, California; Año: 2013 vol. 47 p. 1 - 17
MARIA BELEN SIERRA; SEBASTIAN ACCORDINO; ARIEL RODRIGUEZ-FRIS; MARCELA MORINI; GUSTAVO APPIGNANESI; ARIEL FERNANDEZ STIGLIANO
Protein packing defects heat up interfacial water
European Physical Journal E; Año: 2013 vol. 36 p. 62 - 62
ARIEL FERNANDEZ
The principle of minimal episteric distortion of the water matrix and its role in protein folding
JOURNAL OF CHEMICAL PHYSICS; Lugar: New York; Año: 2013 vol. 139 p. 85101 - 85101
ARIEL FERNANDEZ
COMMUNICATION: Nanoscale electrostatic theory of epistructural fields at the water-protein interface
JOURNAL OF CHEMICAL PHYSICS; Lugar: New York; Año: 2012 vol. 137 p. 231101 - 231101
ARIEL FERNANDEZ; CHRISTOPHER FRASER; RIDGWAY SCOTT
Purposely engineered drug-target mismatches for entropy-based drug optimization
TRENDS IN BIOTECHNOLOGY; Lugar: Londres; Año: 2012 vol. 30 p. 1 - 7
ARIEL FERNANDEZ
Epistructural thermodynamics of soluble proteins
JOURNAL OF CHEMICAL PHYSICS; Lugar: New York; Año: 2012 vol. 136 p. 91101 - 91101
SEBASTIAN ACCORDINO; MARCELA MORINI; MARIA BELEN SIERRA; ARIEL RODRIGUEZ-FRIS; GUSTAVO APPIGNANESI; ARIEL FERNANDEZ
Wrapping mimicking in drug-like small molecules disruptive of protein-protein interfaces
PROTEINS: STRUCTURE, FUNCTION AND GENETICS; Lugar: New York; Año: 2012 vol. 80 p. 1755 - 1765
ARIEL FERNANDEZ
Epistructural tension promotes protein associations
PHYSICAL REVIEW LETTERS; Lugar: New York; Año: 2012 vol. 108 p. 188102 - 188102
SEBASTIAN ACCORDINO; ARIEL RODRIGUEZ-FRIS; GUSTAVO APPIGNANESI; ARIEL FERNANDEZ
A unifying motif of intermolecular cooperativity in protein associations
European Physical Journal E; Año: 2012 vol. 35 p. 59 - 59
ARIEL FERNANDEZ
Biology Avoids Phase Separations
Journal of Physics A: Mathematical and Theoretical; Año: 2011 p. 46468 - 46468
ARIEL FERNANDEZ; MICHAEL LYNCH
Nonadaptive origin of interactome complexity
NATURE; Lugar: Londres; Año: 2011 vol. 474 p. 502 - 505
ARIEL FERNANDEZ
Variational mechanics of water at biological interfaces
JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL; Lugar: Londres; Año: 2011 vol. 44 p. 292001 - 292001
ARIEL FERNANDEZ; YUN-HUEI TZENG; SZE-BI HSU
Subfunctionalization reduces the fitness cost of gene duplication in human by buffering dosage imbalances
BMC GENOMICS; Año: 2011 vol. 12 p. 604 - 604
ARIEL FERNANDEZ; JIANPING CHEN
Human capacitance to dosage imbalance: Coping with inefficient selection
GENOME RESEARCH; Año: 2009 vol. 19 p. 2185 - 2192
ARIEL FERNANDEZ; KRISTINA ROGALE; RIDGWAY SCOTT; HAROLD SCHERAGA
Inhibitor design by wrapping packing defects in HIV-1 proteins
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2004 vol. 101 p. 11640 - 11645
ARIEL FERNANDEZ; R. STEPHEN BERRY
Molecular dimension explored in evolution to promote proteomic complexity
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2004 vol. 101 p. 13460 - 13465
ARIEL FERNANDEZ
Keeping dry and crossing membranes
NATURE BIOTECHNOLOGY; Año: 2004 vol. 22 p. 1081 - 1084
ARIEL FERNANDEZ; HAROLD SCHERAGA
Insufficiently dehydrated hydrogen bonds as determinants for protein interactions
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2003 vol. 100 p. 113 - 118
ARIEL FERNANDEZ; JOZSEF KARDOS; RIDGWAY SCOTT; YUJI GOTO; R. STEPHEN BERRY
Structural defects and the diagnosis of amyloidogenic propensity
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2003 vol. 100 p. 6446 - 6451
ARIEL FERNANDEZ; RIDGWAY SCOTT
Adherence of packing defects in soluble proteins
PHYSICAL REVIEW LETTERS; Año: 2003 vol. 91 p. 18102 - 18102
ARIEL FERNANDEZ; R. STEPHEN BERRY
Proteins with hydrogen-bond packing defects are highly interactive with lipid bilayers: implications for amyloidogenesis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2003 vol. 100 p. 2391 - 2396
ARIEL FERNANDEZ; ANDRES COLUBRI; R. STEPHEN BERRY
Topology to geometry in protein folding: beta-lactoglobulin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2000 vol. 97 p. 14062 - 14066
ARIEL FERNANDEZ; GUSTAVO APPIGNANESI
Variational approach to relaxation in complex free energy landscapes: The polymer folding problem
PHYSICAL REVIEW LETTERS; Lugar: New York; Año: 1997 vol. 78 p. 2668 - 2672
ARIEL FERNANDEZ; HERSCHEL RABITZ
Localization of strain in the RNA backbone and its functional implication
PHYSICAL REVIEW LETTERS; Año: 1992 vol. 69 p. 546 - 549
ARIEL FERNANDEZ
Glassy kinetic barriers between conformational substates in RNA
PHYSICAL REVIEW LETTERS; Año: 1990 vol. 64 p. 2328 - 2331