The folate-driven one carbon cycle is a source of genotoxic formaldehyde

GUILLERMO BURGOS BARRAGAN; NIEK WIT; LUCAS PONTEL; LEE MULDERRIG; THOM BREWER; CHRIS CHANG; KJ PATEL

Conferencia; Responses to DNA damage: from molecule to disease; 2016

The one-carbon carrier tetrahydrofolate (THF) is a genotoxin. Genomic protection against THF requires formaldehyde catabolism (ADH5) and Fanconi anaemia DNA repair pathwayTHF-mediated genotoxicity is caused by its oxidative degradation and concomitant release of formaldehyde. Formaldehyde re-enters the one carbon cycle through detoxification