Discovery of anticonvulsant activity of abietic acid through application of linear discriminant analysis

ALAN TALEVI; MARIANA SELLA-CRAVERO; EDUARDO A. CASTRO; LUIS E. BRUNO-BLANCH

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Elsevier

Año: 2007 vol. 17 p. 1684 - 1690

0960-894X

Linear discriminant analysis was performed to derive discriminant functions based on 2D descriptors and capable of classifying anticonvulsant from non-anticonvulsant compounds. Through application in virtual screening of the discriminant function which performed best in the validation steps, abietic acid was identified as a potential new anticonvulsant agent. The anticonvulsant activity of abietic acid at 30 and 100 mg/kg was confirmed in the Maximal Electroshock Test, both orally and intraperitoneally.