Association between Breed and Antibody Response to Primo-vaccination against Foot and Mouth Disease in Cattle

BRITO, BÁRBARA; DI GIACOMO, SEBASTIÁN; PÉREZ, ANDRÉS; BUCAFUSCO, DANILO; PEGA, JUAN FRANCO; RODRÍGUEZ, LUIS; BORCA, MANUEL VÍCTOR; PÉREZ FILGUEIRA, MARIANO

Greensboro, North Carolina

Congreso; 55st Annual Conference American Association of Veterinary Laboratory Diagnosticians (AAVLD); 2012

AAVLD

Foot-and-mouth disease (FMD) is the most economically important viral disease of wild and domesticated biungulate species and presents a major constraint to international trade of livestock and their associated products. FMD vaccines are routinely used as effective control tools in large regions worldwide and to limit outbreaks during epidemics. Commercial formulations include whole inactivated viral particles as vaccine antigens and protection in cattle has been largely correlated to the induction of neutralizing antibodies. Genetic control of cattle immune adaptive responses has been demonstrated for peptide antigens derived from FMD virus (FMDV) structural proteins. To date, no data has been published regarding the influence of genetics on specific responses to structurally complex FMDV antigens. The aim of this work was to study the association between the antibody response induced in steers after FMDV primary vaccination using commercial vaccines, and the sire?s breed as indicative of genetic-borne variation in the response. Results Total anti-FMDV serum antibody titers induced 45 days post-vaccination were assessed against three virus strains in 377 FMDV-seronegative steers. A significant association was found between anti- FMDV antibody responses and sire?s breed, with lower immune responses found in steers derived from Jersey sires compared to those derived from Holstein sires. No significant intra-breed variation was detected. Conclusions Immune response to primo-vaccination in cattle is affected by the genetic background of the calves, as indicated by the association observed between sire?s breed and humoral adaptive responses to FMD vaccines.