NK CELL-MEDIATED RECRUITMENT OF DENDRITIC CELLS TO THE TUMOR NEGATIVELY IMPACTS ON ANTI-TUMOR CD8 T-CELL PRIMING

XIMENA LUCIA RAFFO; RAUL GERMAN SPALLANZANI; NICOLAS I. TORRES; ANDREA ZIBLAT; CAROLINA I. DOMAICA; NORBERTO W. ZWIRNER; MERCEDES BEATRIZ FUERTES

Mar del Plata, Argentina.

Congreso; LXII Reunión Anual de la Sociedad Argentina de Inmunología; 2014

SAI y SAIC

Spontaneous T cell priming can occur in response to a growing tumor and the presence of activated CD8 T cells has positive prognostic value. However, the innate immune mechanisms that regulate the adaptive antitumor immune responses remain ill-defined. NK cells are the first line of defense against tumors and can secrete cytokines and chemokines. However, a role of NK cells in dendritic cell (DC) recruitment to tumor microenvironment has not been pursued. Thus, the aim of this work was to study the NK cell-mediated DC recruitment and its impact on CD8 T-cell priming during the anti-tumor response. We performed transwell cell migration assays and we found that supernatants from tumor-primed NK cell recruited immature DCs (p