CONICET | Buscador de Institutos y Recursos Humanos

In this work, we intended to inhibit the bioflm synthesis and the metabolism of Gram-positive and Gram-negative bacteria usingtwo highly available wastes (stem and marc) obtained afer the manufacturing of Torrontes wine at Cafayate, Argentina. Winewastes contain a signifcant amount of bioactive compounds, mainly phenolic compounds, which makes them a potential sourceof compounds with benefcial properties to human health, as they could inhibit the virulence of pathogenic bacteria or protect thetissue against oxidative stress. Marc and stem extracts of Torrontes wine were evaluated for their ability to inhibit the metabolism andbioflm production of Pseudomonas aeruginosa and Staphylococcus aureus strains. Te phytochemical composition and antioxidant activity of these extracts were also determined. Te methanol and ethyl acetate extracts, which contained the highest amount of total polyphenolic, exhibited the highest scavenging capacity of ABTS and nitric oxide and the strongest Fe3+ reducing power andexhibited the highest level of inhibition of the bioflm formation and of the metabolic activity in bacterial bioflm. We also noticed a positive correlation between phenolic compounds content, the antioxidant activity, and the anti-bioflm capacity of the winemaking wastes.Tese results display the potentiality of wine wastes to prevent or reduce the formation of bioflm. Moreover, their abundance makes them an attractive and afordable source of antibioflm and antioxidant agents.