INSTITUTO DE BIOPROSPECCION Y FISIOLOGIA VEGETAL
Unidad Ejecutora - UE
Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type Propolis
ZAMPINI CATIANA; ANA L. SALAS; MALDONADO, LUIS; MARÍA INES ISLA
NATURAL PRODUCT COMMUNICATIONS
NATURAL PRODUCTS INC
Lugar: Westerville, Ohio; Año: 2017 vol. 13 p. 167 - 167
Propolis with a botanic origin in Zuccagnia punctata Cav. (Fabaceae), a plant species widely distributed in the Argentinean Monte region, was used to producea standardized propolis extract by biological activity and chemical composition. In this paper the effect on microorganisms isolated from otitis was determined.The extract was active against different Staphylococcus strains with MIC and MBC values (75 and 150 μg DE/mL, 200 and 600 μg DE/mL, respectively) andwith MIC values of 800 μg DE/mL against Proteus mirabilis. A pharmaceutical product, ear drops containing this extract as bioactive was developed. Stabilityof ear drops was evaluated for 6 months, and their biological activity, physical and phytochemical properties were preserved. Ear drops showed inhibitoryactivity on pro-inflammatory enzymes such as lipoxygenase (IC50 values 90 and 100 μg DE/mL), free radical-scavenging effect (SC50 values 23 and 30 μgDE/mL), antihelmintic (LC50 values 70 and 71 μg DE/mL), anti-candida (400 μg DE/mL) and antibacterial activity against Gram-positive bacteria (200 μgDE/mL) at zero time and during six month-storage, respectively. The content of two chalcones, chemical markers of Zuccagnia-type propolis was quantifiedand its level was maintained while stored at room temperature. Its toxicity was also assayed. Our results are interesting since the extract and ear drops ofZuccagnia-type propolis developed could be promising for use in alternative medicine or phytomedicine as antibacterial, anti-candida, antihelmintic, antiinflammatory and antioxidant.