EXPRESIÓN DE GENES INVOLUCRADOS EN EL ESTRÉS OXIDATIVO E INFLAMACIÓN EN NEOPLASIAS HEMATOLÓGICAS

CASAS SILVA, MARÍA JIMENA; LEDESMA ACHEM, MIRYAM EMILSE; LAZARTE, SANDRA STELLA; HARO, ANA CECILIA; MAGDALENA TERAN; AGÜERO AGUILERA AC; ISSÉ, BLANCA ALICIA; MÓNACO, MARÍA EUGENIA

buenos Aires

Congreso; 73° Congreso Argentino de Bioquímica; 2019

Asociación de Bioquímica Argentina

Introduction: Several studies have found evidence of chronic oxidative stress (OxS) in hematologic neoplasia (HN). However, the underlying molecular mechanism associated with OxS and inflammation in these pathologies is currently unclear. Objectives: To analyze the expression of antioxidant enzymes and pro-inflammatory cytokines genes, and relate it to Nrf2 gene expression in subjects with HN. Materials and Methods: A descriptive study was conducted between June 2017 and May 2018. Thirty three HN patients and 22 healthy controls were studied. Catalase (CAT), superoxide dismutase (SOD), peroxiredoxin-2 (PRX-2), IL-6, TNF-α and Nrf2 gene expression was evaluated by RetroTranscription-PCR in real time in peripheral mononuclear blood cells. Results: The HN identified, in frequency order, were: acute leukemia 70%, lymphoproliferative neoplasms (LPN) 12%, myelodysplastic syndromes (MDS) 9% and myeloproliferative neoplasms (MPN) 9%. HN groups showed a significant decrease (p