Doxycycline modifes tau fIbrillization and reduces its toxicity

MEDINA L.; GONZALES LIZARRAGA, MF; SEQUEIRA S.; RAISMAN VOZARI R.; SOCIAS SB.; CHEHÍN R.

Congreso; Reunión Anual de la Sociedad Argentina de Investigación en Neurosciencias; 2020

Sociedad Argentina de Investigación en Neurosciencias

Tauopathies are neurodegenerative diseases characterized by the aggregation of the microtubule associatedprotein tau, without a cure to date. The increasing incidence of these disorders, and the extensive time required forthe development and approval of novel drugs, highlight the need for testing and repurposing known safe moleculesfor new indications. Using biophysical and biochemical techniques we investigated the effect of doxycycline, amember of the tetracycline antibiotic family, on tau amyloid aggregation and neurotoxicity. Doxycycline reduced tau