INVESTIGADORES
SOCIAS Sergio Benjamin
artículos
Título:
The Leucine-Responsive Regulatory Protein, Lrp, Modulates Microcin J25 Intrinsic Resistance in Escherichia coli by Regulating expression of the YojI Microcin Exporter
Autor/es:
SOCÍAS S. BENJAMÍN, VINCENT PAULA A., SALOMÓN RAÚL A
Revista:
JOURNAL OF BACTERIOLOGY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Año: 2009 vol. 191 p. 1343 - 1348
ISSN:
0021-9193
Resumen:
Many Escherichia coli K-12 strains display an intrinsic resistance to the peptide antibiotic microcin J25. In
this study, we present results showing that the leucine-responsive regulatory protein, Lrp, is involved in this
phenotype by acting as a positive regulator of YojI, a chromosomally encoded efflux pump which expels
microcin out of cells. Exogenous leucine antagonizes the effect of Lrp, leading to a diminished expression of the
pump and an increased susceptibility to microcin J25.
this study, we present results showing that the leucine-responsive regulatory protein, Lrp, is involved in this
phenotype by acting as a positive regulator of YojI, a chromosomally encoded efflux pump which expels
microcin out of cells. Exogenous leucine antagonizes the effect of Lrp, leading to a diminished expression of the
pump and an increased susceptibility to microcin J25.
this study, we present results showing that the leucine-responsive regulatory protein, Lrp, is involved in this
phenotype by acting as a positive regulator of YojI, a chromosomally encoded efflux pump which expels
microcin out of cells. Exogenous leucine antagonizes the effect of Lrp, leading to a diminished expression of the
pump and an increased susceptibility to microcin J25.
Escherichia coli K-12 strains display an intrinsic resistance to the peptide antibiotic microcin J25. In
this study, we present results showing that the leucine-responsive regulatory protein, Lrp, is involved in this
phenotype by acting as a positive regulator of YojI, a chromosomally encoded efflux pump which expels
microcin out of cells. Exogenous leucine antagonizes the effect of Lrp, leading to a diminished expression of the
pump and an increased susceptibility to microcin J25.