Dual-hormone glycemic control: impact of extending the ARG algorithm for glucagon dosing

DE BATTISTA, HERNÁN; FUSHIMI, EMILIA; GARELLI, FABRICIO

Congreso; 27º Congreso Argentino de Control Automático; 2020

Asociación Argentina de Control Automático

Artificial pancreas (AP) algorithms can be dividedinto single-hormone and dual-hormone. Single-hormone algorithmsregulate glycemia using insulin as their control signal.On the other hand, dual-hormone algorithms also use glucagonto counteract insulin. In this work, the original single-hormoneARG algorithm is extended in order to transform it to a dual-hormoneAP controller. This new controller (ARGDH) is evaluatedin silico using the UVA/Padova simulator in the adult population,and contrasted to the ARG algorithm. Results suggest that thedual-hormone ARG effectively improves the ARG performance,eliminating hypoglycemia without increasing hyperglycemia norinsulin delivery, at the cost of increasing the system complexity.