Arachidonic acid relaxes rat mesenteric arterial bed involving BK ion channel activation

MARTÍN, PEDRO; MILESI, MARIA VERÓNICA; VECCHIO, LEANDRO; MONCADA, MELISA; ENRIQUE, NICOLÁS

Rio de Janeiro

Congreso; 38th IUPS Congress (International Union of Physiology Sciences); 2017

IUPS (International Union of Physiology Sciences)

Arachidonic acid (AA) is a polyunsaturated fatty acid (PUFA-6) involved in several physiological processes, many times through modulation of ion channels activity. Previously, we reported that 10 µM AA directly activates the high conductance Ca2+ and voltage dependent K+ channel (BK). This effect was observed when the alfa subunit of BK channel was expressed together with the regulatory beta1 subunit, but not in its absence. AA increased the open probability of BK channels and shifted the activation voltage-dependence to the left (ΔV1/2= -55.2 ±4.4 mV, n=3, p