Effects of AR8 and HH1 Equid herpesvirus 1 (EHV-1) strains on BALB-c mice

ZANUZZI, C.; SCROCHI, M.; FUENTEALBA, N.; NISHIDA, F.; PORTIANSKY, E.; MUGLIA, C. I. ; GIMENO, E.; BARBEITO, C.; GALOSI, C.

ARCHIVES OF VIROLOGY

SPRINGER WIEN

Lugar: Viena; Año: 2014 vol. 159 p. 141 - 145

0304-8608

Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.