CONICET | Buscador de Institutos y Recursos Humanos

Plant cell culture bioprocesses have become an alternative source for bioactivecompound production to the traditional extraction technology from plants grown innature or through agricultural techniques. Thus, environmental conditions could makethe supply of these secondary metabolites intermittent and heterogeneous. Therefore,plant cell cultures assure a continuous product supply, homogeneous production,fulfilling GMP requirements. Elicitation has been an extensively used strategy to boostsecondary metabolite production in plant cell cultures. Cyclodextrins, the naturallyoccurring cyclic oligosaccharides of glucose residues, has emerged as an elicitor thatcan trigger plant cell defense responses and secondary metabolite accumulation.Moreover, CDs can form complex with most of the plant secondary compounds, thuscontribute to product removal, which results in the elimination of feedback inhibition ofproduct biosynthesis and also prevents product degradation and toxicity against theplant cells. In the present manuscript, we collect and compare the effects ofcyclodextrins on different secondary metabolite pathways in plant cell cultureprocesses. We review different case studies, which includes the production ofphenylpropanoids, terpenes, alkaloids, naphtoquinones and athraquinones derivatives.In the present manuscript, we collect and compare the effects of cyclodextrins ondifferent secondary metabolite pathways in plant cell culture, which include theproduction of phenylpropanoids, terpenes, alkaloids, naphthoquinones andanthraquinones derivatives.