Prevalence of HLA-B*57:01 allele in Argentinean HIV-1 infected patients

M. MORAGAS; W.H. BELLOSO; M.S. BAQUEDANO; M.I. GUTIERREZ; E. BISSIO; J.M. LARRIBA; F. FAY; P. AULICINO; GUREVICH MESSINA, JUAN MANUEL; M.F. YAUNGUZIAN; A.C. MALDONADO; C. FALISTOCCO; L. SEN; A. MANGANO

TISSUE ANTIGENS

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2015

0001-2815

Hypersensitivity reaction to abacavir (ABC hypersensitivity syndrome, AHS) is strongly associated with the presence of the HLA-B*57:01 allele. This study was designed to estimate the prevalence of HLA-B*57:01 allele in Argentinean HIV-1 infected patients. We analyzed the presence of HLA-B*57:01 allele in 1646 HIV-1 infected patients from different regions of Argentina. This allele was detected in 81 patients; most of them corresponded to patients living in the central region of the country. The prevalence of HLA-B*57:01 was 4.9%, similar to other Caucasian populations and higher than other data reported for South American populations. This strongly supports screening for the presence of HLA-B*57:01 in abacavir treatment of HIV-1 in our country.