INEDES 24797
INSTITUTO DE ECOLOGIA Y DESARROLLO SUSTENTABLE
Unidad Ejecutora - UE
artículos
Título:
Nacetylcysteine, an antioxidant with anti-adipogenic effect on adipocytes.
Autor/es:
GUERRA LN; ROVNER F; GABRIELLI M; CALVO JC; VILA MC; DIZ V; MARTINI, C; SOTO D; PIERALISI A
Revista:
FREE RADICAL BIOLOGY AND MEDICINE
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2017 vol. 108 p. 48 - 49
ISSN:
0891-5849
Resumen:
Reports about antioxidant effect in obesity are contradictory. We showed that N-acetylcysteine (NAC) inhibits cellular lipid accumulation during adipocyte differentiation, through the inhibition of adipogenic transcriptor factors expression, such as PPARγ and, MAPKs phosphorylation (Pieralisi et al,Redox Biol 2016; Soto el al,Redox Rep 2016). Here we evaluated NAC on fully differentiated cells (3T3-L1 adipocytes: AC). Treatments with 0.01 to 5 mM NAC, included in culture media for 5 days, were not toxic. 5mM NAC treatment on AC (ACN) provoked a decrease of 60% in cellular Triglycerides (Tg) content (1.22+0.09 gTg/g protein [AC] vs 0.49+0.03 gTg/g protein [ACN], p
