DONI, DAVIDE; CAVALLARI, EVA; NOGUERA, MARTIN EZEQUIEL; GENTILI, HERNAN GUSTAVO; CAVION, FEDERICA; PARISI, GUSTAVO; FORNASARI, MARIA SILVINA; SARTORI, GEPPO; SANTOS, JAVIER; BELLANDA, MASSIMO; CARBONERA, DONATELLA; COSTANTINI, PAOLA; BORTOLUS, MARCO

Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from Thermus thermophilus

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Lugar: Basilea; Año: 2024 vol. 25

SANTOS J; FERNÁNDEZ VILLAMIL S; DELFINO J.M.; VALSECCHI, WANDA M.

Structural differences between hypoxanthine phosphoribosyltransferase family members highlight opportunities for antiparasitic drug design in neglected diseases

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Lugar: Amsterdam; Año: 2023

SANTIAGO MANSILLA; VERONICA TORTORA; MARIA FLORENCIA PIGNATARO; SANTIAGO SASTRE; IGNACIO CASTRO; CARLOS ROBELLO; ARI ZEIDA; JAVIER SANTOS; LAURA CASTRO

Redox sensitive human mitochondrial aconitase and its interaction with frataxin: In vitro and in silico studies confirm that it takes two to tango

FREE RADICAL BIOLOGY AND MEDICINE; Lugar: Amsterdam; Año: 2023

MARIA GEORGINA HERRERA; MARIA JULIA AMUNDARAIN; JAVIER SANTOS

Biophysical evaluation of the oligomerization and conformational properties of the N-terminal domain of TDP-43

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Lugar: Amsterdam; Año: 2023

SEWELL, KARL E.; GOLA, GABRIEL F.; PIGNATARO, MARÍA FLORENCIA; HERRERA, MARÍA GEORGINA; NOGUERA, MARTÍN E.; OLMOS, JUSTO; RAMÍREZ, JAVIER A.; CAPECE, LUCIANA; ARAN, MARTÍN; SANTOS, JAVIER

Direct Cysteine Desulfurase Activity Determination by NMR and the Study of the Functional Role of Key Structural Elements of Human NFS1

ACS CHEMICAL BIOLOGY; Año: 2023 vol. 18 p. 1534 - 1547

VALSECCHI, WANDA M.; DELFINO, JOSÉ M.; SANTOS, JAVIER; FARAJ, SANTIAGO E.

A problem-based learning activity for enhancing inquiry skills and facilitating conceptual change in a biological chemistry course

CHEMISTRY EDUCATION. RESEARCH AND PRACTICE IN EUROPE; Año: 2023

MARIANA FLORENCIA PIGNATARO; HERRERA, MARÍA GEORGINA; NATALIA BRENDA FERNÁNDEZ; MARTIN ARAN; HERNAN GENTILI; FERNANDO BATTAGLINI; JAVIER SANTOS

Selection of Synthetic Proteins to Modulate the Human Frataxin Function

Biotechnology and Bioengineering; Lugar: Hoboken, New Jersey; Año: 2022

LUCÍA D ESPECHE; KARL ELLIOTH SEWELL; CASTRO, IGNACIO HUGO; LUCIANA CAPECE; MARÍA FLORENCIA PIGNATARO; LILIANA DAIN; JAVIER SANTOS

Conformational stability, dynamics and function of human frataxin: Tryptophan side chain interplay

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Año: 2022

M. FLORENCIA PIGNATARO; PAULA BERGUER; MATIAS BLAUSTEIN; LUIS BREDESTON; PATRICIO CRAIG; CECILIA D'ALESSIO; FERNANDA ELIAS; PAULA FARRÉ; NATALIA FERNANDEZ; GENTILI, HERNÁN; YAMILA GANDOLA; JAVIER GASULLA; GUSTAVO GUDESBLAT; HERRERA, MARÍA GEORGINA; IBAÑEZ LORENA ITATI; TOMAS IDROVO; NADRA, ALEJANDRO DANIEL; DIEGO NOSEDA; CARLOS PAVÁN; MARIA FLORENCIA PAVAN; ROMÁN ERNESTO; RUBERTO LUCAS; NATALIA RUBINSTEIN; MARIA VICTORIA SANCHEZ; SANTOS, JAVIER; WETZLER DIANA; ALICIA ZELADA

Covalent coupling of Spike?s receptor binding domain to a multimeric carrier produces a high immune response against SARS-CoV-2

Scientific Reports; Año: 2022

VALSECCHI, WANDA M.; DELFINO, JOSÉ M.; SANTOS J; FERNÁNDEZ VILLAMIL S

Zoledronate repositioning as a potential trypanocidal drug. Trypanosoma cruzi HPRT an alternative target to be considered

BIOCHEMICAL PHARMACOLOGY; Año: 2021 vol. 188

CONSORCIO ANTICOVID; JAVIER SANTOS,

Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells

Scientific reports; Lugar: Londres; Año: 2020 vol. 10

DONI, DAVIDE; PASSERINI, LEONARDO; AUDRAN, GÉRARD; MARQUE, SYLVAIN R. A.; SCHULZ, MARVIN; SANTOS, JAVIER; COSTANTINI, PAOLA; BORTOLUS, MARCO; CARBONERA, DONATELLA

Effects of fe2+/fe3+ binding to human frataxin and its d122y variant, as revealed by site-directed spin labeling (Sdsl) epr complemented by fluorescence and circular dichroism spectroscopies

International Journal of Molecular Sciences; Lugar: Basilea; Año: 2020 vol. 21 p. 1 - 20

VAZQUEZ, DIEGO S.; ZEIDA, ARI; AGUDELO, WILLIAM A.; MONTES, MÓNICA R.; FERRER-SUETA, GERARDO; SANTOS, JAVIER

Exploring the conformational transition between the fully folded and locally unfolded substates of Escherichia coli thiol peroxidase

PHYSICAL CHEMISTRY CHEMICAL PHYSICS; Lugar: CAMBRIDGE; Año: 2020 vol. 22 p. 9518 - 9533

ARGENTINIAN ANTICOVID CONSORTIUM; JAVIER SANTOS

Structural and Functional Comparison of SARS-CoV-2-SpikeReceptor Binding Domain Produced in​Pichia pastorisandMammalian Cells

Scientific Reports; Año: 2020

CASTRO, IGNACIO HUGO; BRINGAS, MAURO; DONI, DAVIDE; NOGUERA, MARTIN EZEQUIEL; CAPECE, LUCIANA; ARAN, MARTÍN; BLAUSTEIN, MATÍAS; COSTANTINI, PAOLA; SANTOS, JAVIER

Relationship between activity and stability: Design and characterization of stable variants of human frataxin

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Año: 2020 vol. 691

OLMOS, JUSTO; PIGNATARO, MARÍA FLORENCIA; BENÍTEZ DOS SANTOS, ANA BELÉN; BRINGAS, MAURO; KLINKE, SEBASTIÁN; KAMENETZKY, LAURA; VELAZQUEZ, FRANCISCO; SANTOS, JAVIER

A Highly Conserved Iron-Sulfur Cluster Assembly Machinery between Humans and Amoeba Dictyostelium discoideum: The Characterization of Frataxin

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Año: 2020 vol. 21

DALLA RIZZA, JOAQUÍN; RANDALL, LÍA M.; SANTOS, JAVIER; FERRER-SUETA, GERARDO; DENICOLA, ANA

Differential parameters between cytosolic 2-Cys peroxiredoxins, PRDX1 and PRDX2

PROTEIN SCIENCE; Año: 2019 vol. 28 p. 191 - 201

FARAJ, SANTIAGO E.; NOGUERA, MARTÍN E.; DELFINO, JOSÉ MARÍA; SANTOS, JAVIER

Global Implications of Local Unfolding Phenomena, Probed by Cysteine Reactivity in Human Frataxin

Scientific Reports; Año: 2019 vol. 9

GONZÁLEZ-LEBRERO, RODOLFO M.; DEFELIPE, LUCAS; MODENUTTI, CARLOS; ROITBERG, ADRIAN E.; BATASTINI, NICOLAS A.; NOGUERA, MARTÍN E.; SANTOS, JAVIER; ROMAN, ERNESTO A.

Folding and Dynamics Are Strongly pH-Dependent in a Psychrophile Frataxin

JOURNAL OF PHYSICAL CHEMISTRY B - (Print); Lugar: Washington; Año: 2019 vol. 123 p. 7676 - 7686

HERRERA, MARÍA GEORGINA; NOGUERA, MARTIN E.; SEWELL, KARL ELLIOTH; AGUDELO SUÁREZ, WILLIAM ARMANDO; CAPECE, LUCIANA; KLINKE, SEBASTIÁN; SANTOS, JAVIER

The Structure of the Human ACP-ISD11 Heterodimer

BIOCHEMISTRY; Lugar: Washington; Año: 2019

RANDALL, LÍA M.; DALLA RIZZA, JOAQUÍN; PARSONAGE, DEREK; SANTOS, JAVIER; MEHL, RYAN A.; LOWTHER, W. TODD; POOLE, LESLIE B.; DENICOLA, ANA

Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193

FREE RADICAL BIOLOGY AND MEDICINE; Lugar: Amsterdam; Año: 2019 vol. 141 p. 492 - 501

BELLANDA, MASSIMO; MASO, LORENZO; DONI, DAVIDE; BORTOLUS, MARCO; DE ROSA, EDITH; LUNARDI, FEDERICA; ALFONSI, ARIANNA; NOGUERA, MARTÍN EZEQUIEL; HERRERA, MARIA GEORGINA; SANTOS, JAVIER; CARBONERA, DONATELLA; COSTANTINI, PAOLA

Exploring iron-binding to human frataxin and to selected Friedreich ataxia mutants by means of NMR and EPR spectroscopies

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS; Año: 2019 vol. 1867

CASTRO, IGNACIO HUGO; HERRERA, MARÍA GEORGINA; FERRARI, ALEJANDRO; NOGUERA, MARTÍN EZEQUIEL; MASO, LORENZO; BENINI, MONICA; RUFINI, ALESSANDRA; TESTI, ROBERTO; COSTANTINI, PAOLA; SANTOS, JAVIER

Biophysical characterisation of the recombinant human frataxin precursor

FEBS Open Bio; Lugar: Cambridge; Año: 2018 vol. 8 p. 390 - 405

HERRERA MG; PIGNATARO MF; NOGUERA ME; CRUZ KM; SANTOS J

Rescuing the Rescuer: On the Protein Complex between the Human Mitochondrial Acyl Carrier Protein and ISD11

ACS CHEMICAL BIOLOGY; Lugar: Washington; Año: 2018

ANGELANI CR; CARABIAS P; CRUZ KM; DELFINO JM; DE SAUTU M; ESPELT MV; FERREIRA-GOMES MS; GOMEZ GE; MANGIALAVORI IC; MANZI M; PIGNATARO MF; SAFFIOTI NA; SALVATIERRA FRECHOU DM; SANTOS J; SCHWARZBAUM PJ

A Metabolic Control Analysis Approach to Introduce the Study of Systems in Biochemistry: The Glycolytic Pathway in the Red Blood Cell

BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION; Lugar: New York; Año: 2018

NOGUERA, MARTÍN E.; VAZQUEZ, DIEGO S.; FERRER-SUETA, GERARDO; AGUDELO, WILLIAM A.; HOWARD, EDUARDO; RASIA, RODOLFO M.; MANTA, BRUNO; COUSIDO-SIAH, ALEXANDRA; MITSCHLER, ANDRÉ; PODJARNY, ALBERTO; SANTOS, JAVIER

Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants

Scientific Reports; Año: 2017 vol. 7

NOGUERA, MARTÍN E.; SMAL, CLARA; ARAN, MARTÍN; VAZQUEZ, DIEGO S.; HERRERA, MARÍA GEORGINA; ROMAN, ERNESTO A.; ALAIMO, NADINE; GALLO, MARIANA; SANTOS, JAVIER

Insights on the conformational dynamics of human frataxin through modifications of loop-1

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Año: 2017 vol. 636 p. 123 - 137

FARAJ SE; GONZALEZ-LEBRERO RM; ROMAN EA; SANTOS J

Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region

Scientific Reports; Lugar: London; Año: 2016

VALSECCHI, WANDA M.; COUSIDO-SIAH, ALEXANDRA; DEFELIPE, LUCAS A.; MITSCHLER, ANDRÉ; PODJARNY, ALBERTO; SANTOS, JAVIER; DELFINO, JOSÉ M.

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS; Año: 2016 vol. 1864 p. 655 - 666

REYES, ANÍBAL M.; VAZQUEZ, DIEGO S.; ZEIDA, ARI; HUGO, MARTÍN; PIÑEYRO, M. DOLORES; DE ARMAS, MARÍA INÉS; ESTRIN, DARÍO; RADI, RAFAEL; SANTOS, JAVIER; TRUJILLO, MADIA

PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase

FREE RADICAL BIOLOGY AND MEDICINE; Año: 2016 vol. 101 p. 249 - 260

VAZQUEZ DS; DELFINO JM; SANTOS J

Thioredoxin from Escherichia coli as a Role Model of Molecular Recognition, Folding, Dynamics and Function.

PROTEIN AND PEPTIDE LETTERS; Año: 2015 vol. 22 p. 801 - 815

ZEIDA A; REYES MA; LICHTIG P; HUGO M; VAZQUEZ DS; SANTOS J; GONZALEZ FLECHA FL; RADI R; ESTRIN, D; TRUJILLO M

1 Molecular basis of hydroperoxide specificity in peroxiredoxins: the case of AhpE from Mycobacterium tuberculosis

BIOCHEMISTRY; Lugar: Washington; Año: 2015

NOGUERA ME; ROMAN EA; RIGAL RB; COUSIDO-SIAH A; MITSCHLER A; PODJARNY A; SANTOS J

Structural characterization of metal binding to a cold-adapted frataxin

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY; Lugar: Berlin; Año: 2015 vol. 20 p. 653 - 664

RANDALL L ; MANTA B; NELSON KJ; SANTOS J; POOLE LB; DENICOLA A

2 Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Lugar: Amsterdam; Año: 2015

DIEGO S. VAZQUEZ; AGUDELO WA; YONE A; VIZIOLI N; ARÁN M; GONZÁLEZ FLECHA FL; GONZÁLEZ LEBRERO MC; SANTOS J

1 A helix-coil transition induced by the metal ion interaction with a grafted iron-binding site of the CyaY protein family.

DALTON TRANSACTIONS; Lugar: Cambridge; Año: 2014

VAZQUEZ DS; SÁNCHEZ IE; GARROTE A; SICA MP; SANTOS J

2 The E. coli thioredoxin folding mechanism: The key role of the C-terminal helix.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS; Lugar: Amsterdam; Año: 2014

FARAJ SE; ROMAN EA; ARÁN M; GALLO M; SANTOS J

The Alteration of the C-terminal Region of Human Frataxin Distorts its Structural Dynamics and Function

FEBS JOURNAL; Lugar: Londres; Año: 2014

THOMAS AH; ZURBANO BN; LORENTE C; SANTOS J; ROMAN EA; DÁNTOLA ML

Chemical changes in bovine serum albumin photoinduced by pterin

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY; Año: 2014

ERNESTO A ROMÁN; SANTIAGO FARAJ; ALEXANDRA COUSIDO-SIAH; ANDRÉ MITSCHLER; ALBERTO PODJARNY; JAVIER SANTOS

Frataxin from Psychromonas ingrahamii as a model to study stability modulation within the CyaY protein family

BIOCHIMICA ET BIOPHYSICA ACTA, N. GENE STRUCTURE AND EXPRESSION; Lugar: Amsterdam; Año: 2013

SANTIAGO FARAJ; LEANDRO VENTURUTTI; ERNESTO A ROMÁN; CRISTINA MARINO BUSLJE; ASTOR MIGNONE; SILVIO TOSATTO; JOSÉ MARÍA DELFINO; JAVIER SANTOS

The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin

FEBS OPEN BIO; Año: 2013

ANDRÉS BINOLFI; CLAUDIO FERNÁNDEZ; MAURICIO P. SICA; JOSÉ MARÍA DELFINO; JAVIER SANTOS

Recognition between a short unstructured peptide and a partially folded fragment leads to the thioredoxin fold sharing native-like dynamics.

PROTEINS: STRUCTURE, FUNCTION AND GENETICS; Lugar: New York; Año: 2012 vol. 80 p. 1448 - 1464

FEMIA AL; TEMPRANA CF; SANTOS J; CARBAJAL ML; AMOR MS; GRASSELLI M; ALONSO SDEL V

An arsenic fluorescent compound as a novel probe to study arsenic-binding proteins.

PROTEIN JOURNAL; Año: 2012 p. 656 - 666

ROMAN EA; FARAJ SE; GALLO M; SALVAY AG; FERREIRO DU; SANTOS J

Protein Stability and Dynamics Modulation: The Case of Human Frataxin

PLOS ONE; Lugar: San Francisco; Año: 2012 p. 1 - 18

ERNESTO A ROMÁN; PABLO ROSI; MARIANO CAMILO GONZÁLEZ LEBRERO; RODOLFO WUILLOUD; LUIS GONZÁLEZ FLECHA; JOSÉ MARÍA DELFINO; JAVIER SANTOS

Gain of local structure in an amphipathic peptide does not require a specific tertiary framework

PROTEINS: STRUCTURE, FUNCTION AND GENETICS; Año: 2010 p. 1 - 12

ANDRES SALVAY; FRANK GABEL; BERNARD PUCCI; JAVIER SANTOS; EDUARDO I. HOWARD; CHRISTINE EBEL

Structure and Interactions of Fish Type III Antifreeze Protein in Solution.

BIOPHYSICAL JOURNAL; Año: 2010 vol. 99 p. 609 - 618

JAVIER SANTOS; MAURICIO P. SICA; CRISTINA MARINO BUSLJE; ANA GARROTE; MARIO R. ERMÁCORA; JOSÉ MARÍA DELFINO

Structural Selection of a Native Fold by Peptide Recognition. Insights into the Thioredoxin Folding Mechanism.

BIOCHEMISTRY; Lugar: Washington, DC; Año: 2009 vol. 48 p. 595 - 607

CRISTINA MARINO BUSLJE; JAVIER SANTOS; JOSÉ MARÍA DELFINO; MORTEN NIELSEN

Correction for phylogeny, small number of observations and data

BIOINFORMATICS (OXFORD, ENGLAND); Lugar: Oxford,; Año: 2009 vol. 25 p. 1125 - 1131

SALVAY A. G.; SANTOS J.; HOWARD E. I.

Electro-optical properties characterization of Fish Type III Antifreeze Protein

JOURNAL OF BIOLOGICAL PHYSICS; Lugar: Holanda; Año: 2008

SANTOS J; MARINO-BUSLJE C; KLEINMAN C; ERMACORA MR; DELFINO JM

Consolidation of the Thioredoxin Fold by Peptide Recognition: Interaction between E. coli Thioredoxin Fragments 1-93 and 94-108.

BIOCHEMISTRY; Año: 2007 vol. 46 p. 5148 - 5159

JAVIER SANTOS; VALERIA A. RISSO; MAURICIO P. SICA; MARIO R. ERMÁCORA

Effects of serine-to-cysteine mutations on b-lactamase folding

BIOPHYSICAL JOURNAL; Año: 2007 p. 1707 - 1718

GEBHARD, LEOPOLDO G; RISSO, VALERIA A; SANTOS, JAVIER; FERREYRA, RAUL G; NOGUERA, MARTIN E; ERMACORA, MARIO R

Mapping the distribution of conformational information throughout a protein sequence.

JOURNAL OF MOLECULAR BIOLOGY; Año: 2006 vol. 358 p. 280 - 288

SANTOS JAVIER; GEBHARD, LEOPOLDO G; RISSO, VALERIA A; FERREYRA, RAUL G; ROSSI, JUAN P F C; ERMACORA, MARIO R

Folding of an abridged beta-lactamase.

BIOCHEMISTRY; Año: 2004 vol. 43 p. 1715 - 1723

FRATE, M C; LIETZ, E J; SANTOS, J; ROSSI, J P; FINK, A L; ERMACORA, M R

Export and folding of signal-sequenceless Bacillus licheniformis beta-lactamase in Escherichia coli.

EUROPEAN JOURNAL OF BIOCHEMISTRY; Año: 2000 vol. 267 p. 3836 - 3847

SANTOS J; ANTON, E A; BUSLJE, C M; VALDEZ, S N; VILLANUEVA, A L; SICA, M; IACONO, R; MAFFIA, P; POSKUS, E; ERMACORA, M R

Replacement of methionine-161 with threonine eliminates a major by-product of human glutamate decarboxylase 65-kDa variant expression in Escherichia coli.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY; Año: 2000 vol. 31 p. 205 - 212