INBIOMED   24026
INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Unidad Ejecutora - UE
artículos
Título:
Immunotherapy for the treatment of breast cancer
Autor/es:
GOTTARDO, MARIA FLORENCIA; NICOLA, ALEJANDRO; MORENO AYALA, MARIELA A.; ZUCCATO, CAMILA; CANDOLFI, MARIANELA; ASAD, ANTONELA S.; SEILICOVICH, ADRIANA
Revista:
EXPERT OPINION ON BIOLOGICAL THERAPY
Editorial:
INFORMA HEALTHCARE
Referencias:
Lugar: London; Año: 2017 vol. 17
ISSN:
1471-2598
Resumen:
Introduction: Breast cancer is the most common cancer as well as the first cause of death by cancer inwomen worldwide. Although routine treatment improves the outcome of early stage breast cancerpatients, there is no effective therapy for the disseminated disease. Immunotherapy has emerged as apowerful therapeutic strategy for the treatment of many cancers. Although traditionally conceived as anon-immunogenic tumor, breast cancer is now considered a potential target for immunotherapy.Areas covered: In this review, the authors discuss different immunotherapeutic strategies that arecurrently being tested for the treatment of breast cancer: These strategies include: (i) blockade ofimmunological checkpoints, (ii) antitumor vaccines, (iii) regulatory T cell blockade, (iv) adoptive T celltransfer therapy, (iv) adoptive immunotherapy with monoclonal antibodies, and (v) combination ofimmunotherapy with chemotherapy.Expert opinion: A growing body of evidence indicates that immunotherapeutic strategies can benefit alarger cohort of breast cancer patients than hitherto anticipated. Since breast tumors entail multiplemechanisms to impair antitumor immunity, the immunological characterization of individual tumorsand the selection of suitable combinations of chemotherapeutic and immunotherapeutic approachesare required to achieve significant clinical benefit in these patients