INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
Advances in Prostate Cancer
GUERON GERALDINE; COTIGNOLA JAVIER; VAZQUEZ ELBA
Año: 2013 p. 40
In this chapter we describe some of the molecular pathways that govern the inflammatory milieu leading to malignant prostate transformation. The ability to orchestrate cytokines, chemokines and their receptors, trigger oxidative/nitrosative stress and favor antioxidant imbalance prompts a pro-inflammatory scenario, that alters and recruits host inflammatory and stem cells, contributing to the survival and expansion of tumors. We also discuss the role of microRNAs and their targets providing new insights on their contribution to the link between inflammation and prostate cancer and assess the vascular properties of cancer cells. The understanding of the crosstalk between pro-inflammatory mediators and the host response will give rise to promising targets for chemoprevention of inflammation-associated carcinogenesis.