Endothelial and astroglial alterations in in vitro and in vivo models of Alzheimer?s disease. Evidence of cell activation and autophagic induction

TODERO MF; KOTLER M.L; POMILIO C; VINUESA A; BEAUQUIS J; GOROJOD RM; ALAIMO A; SARAVIA F

Buenos Aires

Congreso; 2nd FALAN CONGRESS 2016; 2016

FALAN IBRO LARC SAN

Alzheimer?s disease (AD) is the principal cause of dementia in the elderly. The overproduction of Amyloid-β peptides (Aβ) and their aggregation into senile plaques are recognized hallmarks in AD. Aβ is able to affect neurons and synapsis, but also it activates glial and endothelial cells -components of the neurovascular unit- altering brain homeostasis. In this study, we characterized astroglial and vascular alterations in in vitro conditions and using a mouse model of AD. Before plaque deposition, AD mice exhibited less astrocytes (p