Insulin-chitosan interactions for the protein nanocarriers design

C. PRUDKIN; K. MARTÍNEZ; O. PEREZ

Buenos Aires

Congreso; II Workshop on Bio-degradable Polymers and Biocomposites III Workshop BIOPURFIL, Bio-based Polyurethane Composites with Natural Fillers; 2015

Vera Alvarez Mirta Aranguren Patricia Cerrutti Viviana Cyras M. Laura Foresti Nora Francois Pablo Froimowicz Lidia Herrera Liliana Manfredi Mirna Mosiewicki Pablo Stefani Analia Vazquez

This contribution is part of a more extensive project which aim is the development of nanocarriers for insulin. These nanocarriers will be generated under the concept of molecular "self-assembly"[1]. Such matrices will be employed in the encapsulation and controlled delivery for insulin [2]. The encapsulating material is chitosan (CH) [3], which is a biodegradable, biocompatible and non-toxic polysaccharide derived from chitin. Punctually, the specific objective here was to quantify the interactions degree for these chemical species at pH values where the electrostatic interactions would be favored