Induction of the tolerogenic dendritic cells DC-10 into the decidua: the contribution of trophoblast cells

HAUK, VANESA; BLEJER, JORGELINA; PEREZ LEIROS, CLAUDIA; SCHAFIR, ANA; FERNANDEZ, LAURA ; GRASSO, ESTEBAN ; GORI, MARIA SOLEDAD; LARA, BRENDA; GRASSI, ALEJANDRA; RAMHORST ROSSANA

Mar del Plata

Congreso; REUNIÓN CONJUNTA SAIC SAI&FAIC SAFIS 2022; 2022

SAIC SAI SAFIS FAIC

Immunomodulation and tolerance induction are strictly required during pregnancy. A novel and distinctive subset of HLA-G+ tolerogenic dendritic cell, DC-10, was found increased in first-trimester decidua. Recently, we showed that decidualized cells can condition maternal monocytes to DC-10 profile during the pre-implantation period. Here we aimed to explore the potential contribution of DC-10 in first-trimester decidua and the impact of trophoblast cells in its induction. First, we performed an integrated bioinformatic analysis since public array-based data. We found 212 up-regulated genes in DC-10 relative to mature and immature DC (p