Electrochemical Arrays for Bioassay Applications

CORTÓN, EDUARDO; SUSAN R. MIKKELSEN

Trends in Bioelectroanalysis

Elsevier

Año: 2016; p. 103 - 141

This Chapter presents a survey ofdevelopments and bioassay applications of individually-addressable electrochemicalarrays covering the past two decades and including over 90 references. Manydifferent array designs have been fabricated, from macroscopic devices thathave two to four sensing elements to ultramicroelectrode arrays containing asmany as 12,000 individually-addressable micrometer-sized working electrodes.Some inexpensively fabricated arrays are intended for single sample analysisand are disposable, while others are encapsulated for incorporation intoreusable microfluidic systems. Devices and assays are grouped according to thetypes of modifications done to the sensing elements, and sections are includedto consider unmodified elements as well as modifications with enzymes, antibodiesor antigens, nucleic acids, in addition to viable cells and tissues. Sometrends have been identified, and possible future directions are suggested.