IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
In vivo hemin pre-conditioning targets the vascular and immunological compartments and restrains prostate tumor development
Autor/es:
JAWORSKI, FELIPE MARTÍN; MEISS, ROBERTO; AHMED, ASIF; COMPAGNO, DANIEL; GENTILINI, LUCAS; ORTIZ, EMILIANO GERMÁN; NAVONE, NORA; LADERACH, DIEGO JOSÉ; GUERON, GERALDINE; BERGUER, PAULA MERCEDES; RABINOVICH, GABRIEL ADRIÁN; VAZQUEZ, ELBA S.
Revista:
MEDICINA (BUENOS AIRES)
Editorial:
MEDICINA (BUENOS AIRES)
Referencias:
Año: 2016
ISSN:
0025-7680
Resumen:
?Pre-conditioning? strategies constitute a relatively unexplored and exciting opportunity to shape tumor fate. In this study we used hemin, an inducer of Heme Oxygenase-1 (HO-1), in an in vivo pre-conditioning model to assess prostate cancer (PCa) development. The stroma of immunocompetent C57BL/6 mice (n=5) was conditioned by subcutaneous administration of hemin prior to TRAMP-C1 (murine PCa cell line TC1) tumor challenge. Pre-conditioning resulted in increased tumor latency and decreased initial growth rate (P
